MYL12B and PNKD

Number of citations of the paper that reports this interaction (PubMedID 15188056)
0

Data Source:
HPRD (two hybrid, in vitro)

		MYL12B	PNKD
Description		myosin light chain 12B	PNKD metallo-beta-lactamase domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Brush Border Cell Cortex Myosin Complex Myosin II Complex Myofibril Z Disc Protein-containing Complex Apical Part Of Cell Extracellular Exosome	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Presynaptic Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Myosin Heavy Chain Binding Metal Ion Binding	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Shape	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Appendicular lean mass ( 33097823) Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: DAPK1 HSPB1 MYLIP NSMF PNKD	7 interacting genes: APP ENO3 KCTD9 KLHL20 MAGEA11 MYL12B UBC
Entrez ID		103910	25953
HPRD ID		10095	11369
Ensembl ID		ENSG00000118680	ENSG00000127838
Uniprot IDs		O14950	Q8N490
PDB IDs
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Kinase C Signaling Regulation Of NMDA Receptor Activity Plasma Membrane Protein Kinase C Inhibitor Activity Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Programmed Cell Death Cellular Response To Hydroperoxide Regulation Of Apoptotic Process Postsynaptic Density Defense Response To Tumor Cell Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Regulation Of Translation Regulation Of Autophagy Cytoskeleton Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Contractile Muscle Fiber Lactate Metabolic Process Methylglyoxal Metabolic Process Regulation Of Synaptic Transmission, Dopaminergic Aldehyde Catabolic Process Regulation Of Dopamine Metabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde Neuromuscular Process Controlling Posture Negative Regulation Of Neurotransmitter Secretion Apical Dendrite Regulation Of Neuron Projection Development Positive Regulation Of Neuron Migration Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Refolding Presynaptic Cytosol
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