MYL12B

Description		myosin light chain 12B
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Brush Border Cell Cortex Myosin Complex Myosin II Complex Myofibril Z Disc Protein-containing Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Shape
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		5 interacting genes: DAPK1 HSPB1 MYLIP NSMF PNKD
Entrez ID		103910
HPRD ID		10095
Ensembl ID		ENSG00000118680
Uniprot IDs		O14950
PDB IDs
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Kinase C Signaling Regulation Of NMDA Receptor Activity Plasma Membrane Protein Kinase C Inhibitor Activity Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Programmed Cell Death Cellular Response To Hydroperoxide Regulation Of Apoptotic Process Postsynaptic Density Defense Response To Tumor Cell Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Regulation Of Translation Regulation Of Autophagy Cytoskeleton Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Contractile Muscle Fiber Lactate Metabolic Process Methylglyoxal Metabolic Process Regulation Of Synaptic Transmission, Dopaminergic Aldehyde Catabolic Process Regulation Of Dopamine Metabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde Neuromuscular Process Controlling Posture Negative Regulation Of Neurotransmitter Secretion Apical Dendrite Regulation Of Neuron Projection Development Positive Regulation Of Neuron Migration Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Refolding Presynaptic Cytosol
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