TFAP2C and CITED4

Number of citations of the paper that reports this interaction (PubMedID 11744733)
0

Data Source:
HPRD (in vitro)

		TFAP2C	CITED4
Description		transcription factor AP-2 gamma	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Stem Cell Population Maintenance Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Population Maintenance Epithelial Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Skin Development Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Sebaceous Gland Development Stem Cell Differentiation Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morula Formation	Regulation Of DNA-templated Transcription Response To Estrogen Positive Regulation Of DNA-templated Transcription
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors Specification of primordial germ cells Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells	Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)
Interacting Genes		12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4	4 interacting genes: EP300 TFAP2A TFAP2B TFAP2C
Entrez ID		7022	163732
HPRD ID		03361	06011
Ensembl ID		ENSG00000087510	ENSG00000179862
Uniprot IDs		Q92754	Q96RK1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process LBD Domain Binding Response To Estrogen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Positive Regulation Of Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Cell Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Establishment Of Planar Polarity Involved In Nephron Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Nuclear Transport Nucleocytoplasmic Transport Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction Response To Hormone Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Vasculogenesis Cellular Senescence Intracellular Signal Transduction Regulation Of Cell Communication	Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retina Layer Formation Forelimb Morphogenesis RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Skin Development DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Animal Organ Development Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Propionylation Anatomical Structure Morphogenesis Swimming Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Metabolic Process Peptidyl-lysine Butyrylation Negative Regulation Of DNA-templated Transcription Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Chromatin Binding Histone Crotonyltransferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Optic Cup Structural Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Programmed Cell Death Nervous System Development Sequence-specific Double-stranded DNA Binding Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Positive Regulation Of RNA Metabolic Process Protein Propionyltransferase Activity Fat Cell Differentiation Positive Regulation Of T Cell Differentiation Histone H3K27 Acetyltransferase Activity
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