TFAP2C and ZFAND4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TFAP2C	ZFAND4
Description		transcription factor AP-2 gamma	zinc finger AN1-type containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Stem Cell Population Maintenance Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Population Maintenance Epithelial Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Skin Development Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Sebaceous Gland Development Stem Cell Differentiation Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morula Formation
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors Specification of primordial germ cells Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)	Mean corpuscular volume ( 29403010) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4	1 interacting genes: TFAP2C
Entrez ID		7022	93550
HPRD ID		03361	16494
Ensembl ID		ENSG00000087510	ENSG00000172671
Uniprot IDs		Q92754	A8K8Q5 J3KPC0 Q86WR3 Q86XD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process LBD Domain Binding Response To Estrogen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Positive Regulation Of Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Cell Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Establishment Of Planar Polarity Involved In Nephron Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Nuclear Transport Nucleocytoplasmic Transport Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction Response To Hormone Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Vasculogenesis Cellular Senescence Intracellular Signal Transduction Regulation Of Cell Communication	Inner Cell Mass Cell Differentiation Morula Formation Sebaceous Gland Development Forebrain Neuron Fate Commitment Germ-line Stem Cell Population Maintenance Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Keratinocyte Development Mammary Gland Epithelial Cell Proliferation Trophectodermal Cell Differentiation Neuron Fate Commitment Hair Follicle Development Skin Development Somatic Stem Cell Population Maintenance Regulation Of Epidermis Development Hair Cycle Process Cerebral Cortex Development Male Gonad Development Stem Cell Differentiation Stem Cell Population Maintenance Maintenance Of Cell Number Epithelial Cell Development Gonad Development Epithelial Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Cell Fate Commitment Reproductive Structure Development
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