TFAP2C and CITED1

Number of citations of the paper that reports this interaction (PubMedID 11744733)
0

Data Source:
HPRD (in vitro)

		TFAP2C	CITED1
Description		transcription factor AP-2 gamma	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity LBD Domain Binding Co-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Stem Cell Population Maintenance Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Population Maintenance Epithelial Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Skin Development Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Sebaceous Gland Development Stem Cell Differentiation Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morula Formation	Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleocytoplasmic Transport Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Melanocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Lipopolysaccharide Response To Insulin Response To Cytokine Response To Type II Interferon Melanin Biosynthetic Process Regulation Of Apoptotic Process Pigmentation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Mesenchymal To Epithelial Transition SMAD Protein Signal Transduction Labyrinthine Layer Development Response To Interleukin-1 Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-6 Response To Interleukin-9 Response To Interleukin-11 Response To Parathyroid Hormone Response To Transforming Growth Factor Beta Regulation Of Kidney Development Positive Regulation Of Mesenchymal Stem Cell Proliferation
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors Specification of primordial germ cells Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells	Activation of the TFAP2 (AP-2) family of transcription factors Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)	Autism spectrum disorder ( 34069769) Chloride levels ( 29403010) Sodium levels ( 29403010)
Interacting Genes		12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4	8 interacting genes: CREBBP EP300 ESR1 HSPA8 LNX1 SMAD4 TFAP2B TFAP2C
Entrez ID		7022	4435
HPRD ID		03361	02146
Ensembl ID		ENSG00000087510	ENSG00000125931
Uniprot IDs		Q92754	Q99966
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process LBD Domain Binding Response To Estrogen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Positive Regulation Of Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Cell Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Establishment Of Planar Polarity Involved In Nephron Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Nuclear Transport Nucleocytoplasmic Transport Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction Response To Hormone Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Vasculogenesis Cellular Senescence Intracellular Signal Transduction Regulation Of Cell Communication	Transcription Coactivator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Histone H3K27 Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Chromatin Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Nucleic Acid Metabolic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sebaceous Gland Development RNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Differentiation Peptidyl-lysine Acetylation Male Gonad Development Nucleobase-containing Compound Biosynthetic Process Regulation Of Cellular Response To Heat Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Mammary Gland Epithelial Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gonad Development Regulation Of Innate Immune Response Positive Regulation Of RNA Metabolic Process Acetyltransferase Activity Cellular Response To Lectin Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Macromolecule Metabolic Process Muscle Tissue Development Uterus Development
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