GCKR

Gene Name		glucokinase (hexokinase 4) regulator
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Protein Import Into Nucleus, Translocation Cellular Glucose Homeostasis Carbohydrate Metabolic Process Hexose Transport Pathogenesis Response To Fructose Regulation Of Glucose Transport Glucose Transport Negative Regulation Of Glucokinase Activity Positive Regulation Of Glucokinase Activity Small Molecule Metabolic Process Urate Metabolic Process Transmembrane Transport Triglyceride Homeostasis
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of Glucokinase by Glucokinase Regulatory Protein Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs
Diseases
GWAS		Breast size ( 22747683) C-reactive protein ( 18439548 21300955) Calcium levels ( 20705733) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Crohn's disease ( 21102463) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 22508271) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Non-albumin protein levels ( 22558069) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Platelet counts ( 22139419) Serum albumin level ( 23022100) Serum total protein level ( 23022100) Sex hormone-binding globulin levels ( 22829776) Triglycerides ( 23726366 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Urate levels ( 20884846 20139978 23263486) Uric acid levels ( 19503597) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-protein Interactions		3 interactors: CDKN1A GCK TRAF2
Entrez ID		2646
HPRD ID		02909
Ensembl ID		ENSG00000084734
Uniprot IDs		F5H1P6 Q14397
PDB IDs		4BB9 4BBA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Defense Response Positive Regulation Of MAP Kinase Activity Cellular Response To Extracellular Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Detection Of Glucose Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Cell Activation Intracellular Signal Transduction Cellular Response To Organic Substance Intestinal Epithelial Cell Maturation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Epinephrine Secretion Immune System Process Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Lymphocyte Activation Regulation Of Protein Secretion Regulation Of Protein Metabolic Process Cellular Response To UV-B Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Response To Extracellular Stimulus
Tagcloud ?		aetiology ancestry college direction equivocal european europeans genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand