SUZ12 and SLC2A2

		SUZ12	SLC2A2
Description		SUZ12 polycomb repressive complex 2 subunit	solute carrier family 2 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex	Cytoplasm Plasma Membrane Brush Border Cell-cell Junction Membrane Apical Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding	Fructose Transmembrane Transporter Activity Galactose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation	Carbohydrate Metabolic Process Fructose Transmembrane Transport Galactose Transmembrane Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus D-glucose Import Transmembrane Transport Dehydroascorbic Acid Transport D-glucose Transmembrane Transport
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	Cellular hexose transport Regulation of gene expression in beta cells Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption
Drugs			Streptozocin
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Blood sugar levels ( 29403010) C-reactive protein levels ( 30388399) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 28270201) Gamma glutamyl transferase levels ( 33339817) Glycated hemoglobin levels ( 34059833 28898252) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Night sleep phenotypes ( 27126917) Response to metformin in type 2 diabetes (HbA1c reduction) ( 27500523) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		18 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 RNF10 UBC UBE2I WDR77	3 interacting genes: KPNA2 PDX1 PRKACA
Entrez ID		23512	6514
HPRD ID		06949	00685
Ensembl ID		ENSG00000178691	ENSG00000163581
Uniprot IDs		J3QQW9 Q15022	P11168 Q6PAU8
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly	Cellular Response To Acadesine Carbohydrate Homeostasis Response To Chlorate Regulation Of Insulin Secretion Response To Monosaccharide Regulation Of Peptide Hormone Secretion Promoter-specific Chromatin Binding Protein Transport Response To Carbohydrate Glucose Homeostasis Response To Glucose Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Insulin Secretion Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Hormone Secretion Regulation Of Protein Secretion Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Protein Transport Nuclear Transport Nucleocytoplasmic Transport CAMP-dependent Protein Kinase Activity Transdifferentiation Response To Iron(II) Ion Establishment Of Protein Localization Channel Activator Activity Sex Chromatin Carbohydrate Mediated Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Type B Pancreatic Cell Differentiation Exocrine Pancreas Development Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Establishment Of Protein Localization Host Cell NLS-dependent Protein Nuclear Import Complex Intracellular Transport Of Virus CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
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