CALCRL and CALCA

Number of citations of the paper that reports this interaction (PMID 9620797)
228

Data Source:
HPRD (in vitro, in vivo)

		CALCRL	CALCA
Gene Name		calcitonin receptor-like	calcitonin-related polypeptide alpha
Image
Gene Ontology Annotations	Cellular Component	Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G-protein Coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity	Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Protein Complex Binding Identical Protein Binding
	Biological Process	Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Heart Development Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus	Endothelial Cell Proliferation Vasculature Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate G-protein Coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Embryo Implantation Aging Feeding Behavior Regulation Of Blood Pressure Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Ossification Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Negative Regulation Of Neurological System Process Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Smooth Muscle Contraction Response To Pain Regulation Of Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cytosolic Calcium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Amyloids Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	7 interactors: BBS1 BBS4 CALCRL ECE1 NRD1 RAMP1 RAMP2
Entrez ID		10203	796
HPRD ID		11809	00238
Ensembl ID		ENSG00000064989	ENSG00000110680
Uniprot IDs		Q16602	P01258 P06881
PDB IDs		3AQF 3N7P 3N7R 3N7S	1LS7 2JXZ
Enriched GO Terms of Interacting Partners?		Receptor Internalization Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Endocytosis Vascular Smooth Muscle Cell Development G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability G-protein Coupled Receptor Internalization Vasculature Development Regulation Of Vasculogenesis Vesicle-mediated Transport Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Differentiation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway CAMP Biosynthetic Process Plasma Membrane Organization Female Pregnancy Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Cardiovascular System Development CAMP Metabolic Process Blood Circulation Calcium Ion Transport Cyclic Purine Nucleotide Metabolic Process Regulation Of Vasodilation Protein Localization To Membrane Cyclic Nucleotide Biosynthetic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Blood Vessel Morphogenesis Endomembrane System Organization Regulation Of Signal Transduction Signal Transduction Regulation Of Heart Rate Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Signaling Blood Vessel Development Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway	Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Cardiovascular System Development Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Development Anatomical Structure Morphogenesis Protein Localization To Plasma Membrane Nonmotile Primary Cilium Assembly Regulation Of Blood Pressure Protein Transport Establishment Of Protein Localization CAMP Biosynthetic Process Plasma Membrane Organization Photoreceptor Cell Maintenance CAMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Protein Localization Blood Circulation Calcium Ion Transport Angiogenesis Cyclic Nucleotide Biosynthetic Process Receptor-mediated Endocytosis Protein Localization To Membrane Retina Homeostasis Blood Vessel Morphogenesis Endomembrane System Organization Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Calcitonin Catabolic Process Substance P Catabolic Process Endothelin Maturation Cellular Response To Sucrose Stimulus Cellular Protein Localization Blood Vessel Development Regulation Of Systemic Arterial Blood Pressure Vasculature Development Vesicle-mediated Transport Anatomical Structure Development Intracellular Transport Neuropeptide Catabolic Process Endocytosis Positive Regulation Of Cilium Assembly Sensory Processing Basement Membrane Assembly Developmental Process
Tagcloud ?			11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity
Tagcloud (Difference) ?			11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity
Tagcloud (Intersection) ?