CALCRL

Gene Name		calcitonin receptor-like
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Gene Ontology Annotations	Cellular Component	Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G-protein Coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity
	Biological Process	Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Heart Development Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		10203
HPRD ID		11809
Ensembl ID		ENSG00000064989
Uniprot IDs		Q16602
PDB IDs		3AQF 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Receptor Internalization Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Endocytosis Vascular Smooth Muscle Cell Development G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability G-protein Coupled Receptor Internalization Vasculature Development Regulation Of Vasculogenesis Vesicle-mediated Transport Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Differentiation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway CAMP Biosynthetic Process Plasma Membrane Organization Female Pregnancy Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Cardiovascular System Development CAMP Metabolic Process Blood Circulation Calcium Ion Transport Cyclic Purine Nucleotide Metabolic Process Regulation Of Vasodilation Protein Localization To Membrane Cyclic Nucleotide Biosynthetic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Blood Vessel Morphogenesis Endomembrane System Organization Regulation Of Signal Transduction Signal Transduction Regulation Of Heart Rate Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Signaling Blood Vessel Development Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway
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