CALCRL and RAMP2

Number of citations of the paper that reports this interaction (PMID 9620797)
228

Data Source:
HPRD (in vitro)

		CALCRL	RAMP2
Gene Name		calcitonin receptor-like	receptor (G protein-coupled) activity modifying protein 2
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Gene Ontology Annotations	Cellular Component	Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Cell Surface Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G-protein Coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity	Protein Binding Protein Transporter Activity Coreceptor Activity
	Biological Process	Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Heart Development Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Development Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	5 interactors: CALCA CALCRL IAPP SLC31A2 VIPR1
Entrez ID		10203	10266
HPRD ID		11809	05516
Ensembl ID		ENSG00000064989	ENSG00000131477
Uniprot IDs		Q16602	K7EMD3 O60895
PDB IDs		3AQF 3N7P 3N7R 3N7S	2XVT 3AQE 3AQF
Enriched GO Terms of Interacting Partners?		Receptor Internalization Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Endocytosis Vascular Smooth Muscle Cell Development G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability G-protein Coupled Receptor Internalization Vasculature Development Regulation Of Vasculogenesis Vesicle-mediated Transport Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Differentiation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway CAMP Biosynthetic Process Plasma Membrane Organization Female Pregnancy Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Cardiovascular System Development CAMP Metabolic Process Blood Circulation Calcium Ion Transport Cyclic Purine Nucleotide Metabolic Process Regulation Of Vasodilation Protein Localization To Membrane Cyclic Nucleotide Biosynthetic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Blood Vessel Morphogenesis Endomembrane System Organization Regulation Of Signal Transduction Signal Transduction Regulation Of Heart Rate Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Signaling Blood Vessel Development Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway	Negative Regulation Of Bone Resorption G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Receptor Internalization Regulation Of Bone Remodeling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Tissue Remodeling Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Feeding Behavior Regulation Of CAMP Metabolic Process Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Receptor-mediated Endocytosis Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization Cellular Metal Ion Homeostasis Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cellular Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Sucrose Endothelial Cell Proliferation Metal Ion Homeostasis Cellular Copper Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction CAMP Biosynthetic Process Copper Ion Homeostasis Cellular Chemical Homeostasis
Tagcloud ?			abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Difference) ?			abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Intersection) ?