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CALCRL and ADM
Number of citations of the paper that reports this interaction (PMID
9620797
)
228
Data Source:
HPRD
(in vitro, in vivo)
CALCRL
ADM
Gene Name
calcitonin receptor-like
adrenomedullin
Image
Gene Ontology Annotations
Cellular Component
Lysosome
Endosome
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Molecular Function
Adrenomedullin Receptor Activity
Calcitonin Gene-related Peptide Receptor Activity
G-protein Coupled Receptor Activity
Calcitonin Receptor Activity
Protein Binding
Protein Transporter Activity
Receptor Binding
Hormone Activity
Protein Binding
Adrenomedullin Receptor Binding
Biological Process
Angiogenesis
CAMP Biosynthetic Process
Calcium Ion Transport
Regulation Of Muscle Contraction
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Heart Development
Protein Transport
Positive Regulation Of CAMP Biosynthetic Process
Receptor Internalization
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Cellular Response To Sucrose Stimulus
Vasculogenesis
Response To Hypoxia
Neural Tube Closure
Regulation Of The Force Of Heart Contraction
G-protein Coupled Receptor Internalization
CAMP Biosynthetic Process
Progesterone Biosynthetic Process
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Heart Development
Female Pregnancy
Aging
Blood Circulation
Androgen Metabolic Process
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Cold
Response To Wounding
Positive Regulation Of Heart Rate
CAMP-mediated Signaling
Positive Regulation Of CAMP Biosynthetic Process
Organ Regeneration
Neuron Projection Regeneration
Receptor Internalization
Response To Lipopolysaccharide
Response To Insulin
Odontogenesis Of Dentin-containing Tooth
Response To Starvation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Vascular Permeability
Positive Regulation Of Angiogenesis
Negative Regulation Of Vasoconstriction
Positive Regulation Of Vasodilation
Hormone Secretion
Developmental Growth
Response To Glucocorticoid
Branching Involved In Labyrinthine Layer Morphogenesis
Spongiotrophoblast Layer Development
Vascular Smooth Muscle Cell Development
Positive Regulation Of Vasculogenesis
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
G alpha (s) signalling events
Calcitonin-like ligand receptors
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Class B/2 (Secretin family receptors)
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
G alpha (s) signalling events
Calcitonin-like ligand receptors
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Blood pressure (
21909110
)
Circulating vasoactive peptide levels (
23381795
)
Diastolic blood pressure (
21909115
)
HDL cholesterol (
20686565
)
Schizophrenia, bipolar disorder and depression (combined) (
20713499
)
Systolic blood pressure (
21909115
)
Protein-Protein Interactions
6 interactors:
ADM
CALCA
CRCP
RAMP1
RAMP2
RAMP3
4 interactors:
CALCRL
CFH
EDN1
MME
Entrez ID
10203
133
HPRD ID
11809
00061
Ensembl ID
ENSG00000064989
Uniprot IDs
Q16602
P35318
PDB IDs
3AQF
3N7P
3N7R
3N7S
2FLY
2L7S
Enriched GO Terms of Interacting Partners
?
Receptor Internalization
Receptor Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of CAMP Biosynthetic Process
Positive Regulation Of CAMP Metabolic Process
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Regulation Of CAMP Biosynthetic Process
Receptor-mediated Endocytosis
Regulation Of CAMP Metabolic Process
Endocytosis
Vascular Smooth Muscle Cell Development
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Vasculogenesis
Negative Regulation Of Vascular Permeability
G-protein Coupled Receptor Internalization
Vasculature Development
Regulation Of Vasculogenesis
Vesicle-mediated Transport
Protein Localization To Plasma Membrane
Vascular Smooth Muscle Cell Differentiation
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
CAMP Biosynthetic Process
Plasma Membrane Organization
Female Pregnancy
Regulation Of Vascular Permeability
Positive Regulation Of Vasodilation
Cardiovascular System Development
CAMP Metabolic Process
Blood Circulation
Calcium Ion Transport
Cyclic Purine Nucleotide Metabolic Process
Regulation Of Vasodilation
Protein Localization To Membrane
Cyclic Nucleotide Biosynthetic Process
Smooth Muscle Cell Differentiation
Positive Regulation Of Cellular Metabolic Process
Blood Vessel Morphogenesis
Endomembrane System Organization
Regulation Of Signal Transduction
Signal Transduction
Regulation Of Heart Rate
Cyclic Nucleotide Metabolic Process
Response To Steroid Hormone
Signaling
Blood Vessel Development
Regulation Of Signaling
Regulation Of Phosphorus Metabolic Process
Cell Communication
Cell Surface Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Sensory Perception Of Pain
Regulation Of CAMP Biosynthetic Process
Regulation Of Systemic Arterial Blood Pressure
Regulation Of CAMP Metabolic Process
Regulation Of Smooth Muscle Cell Proliferation
Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway
Cellular Response To Sucrose Stimulus
Protein Kinase C Deactivation
Regulation Of Muscle Contraction
Cellular Response To Mineralocorticoid Stimulus
Response To Salt
Rhythmic Excitation
Regulation Of Blood Pressure
Cellular Response To UV-A
Nitric Oxide Transport
Response To Prostaglandin F
Positive Regulation Of Chemokine-mediated Signaling Pathway
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Vein Smooth Muscle Contraction
Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Hormone Levels
Regulation Of Systemic Arterial Blood Pressure By Endothelin
Epithelial Fluid Transport
Creatinine Metabolic Process
Regulation Of Inflammatory Response
Positive Regulation Of Sarcomere Organization
Rhythmic Synaptic Transmission
Response To UV-A
Blood Circulation
Response To Ozone
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Aging
Angiogenesis
Cellular Response To UV-B
Artery Smooth Muscle Contraction
Response To Muscle Stretch
Tonic Smooth Muscle Contraction
Maternal Process Involved In Parturition
Positive Regulation Of Receptor Biosynthetic Process
Positive Regulation Of Odontogenesis
Angiotensin Maturation
Cellular Response To Organic Substance
Blood Vessel Morphogenesis
Regulation Of Angiotensin Metabolic Process
Complement Activation, Alternative Pathway
Positive Regulation Of Renal Sodium Excretion
Regulation Of Smooth Muscle Cell Apoptotic Process
Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin
Positive Regulation Of Prostaglandin Secretion
Tagcloud
?
7mg
adriamycin
cap
cddp
clinic
cpm
cr
cyclophosphamide
d1
d10
divided
home
hrs
infusion
nausea
nephrotoxicities
ns
outpatient
ovarian
pr
remarkably
saline
schedule
schedules
side
sqm
suitable
twenty
vomiting
Tagcloud (Difference)
?
7mg
adriamycin
cap
cddp
clinic
cpm
cr
cyclophosphamide
d1
d10
divided
home
hrs
infusion
nausea
nephrotoxicities
ns
outpatient
ovarian
pr
remarkably
saline
schedule
schedules
side
sqm
suitable
twenty
vomiting
Tagcloud (Intersection)
?