ALYREF and THOC1

Number of citations of the paper that reports this interaction (PMID 17190602)
119

Data Source:
BioGRID (pull down)

		ALYREF	THOC1
Gene Name		Aly/REF export factor	THO complex 1
Image
Gene Ontology Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge
	Molecular Function	Nucleotide Binding Single-stranded DNA Binding Protein Binding Poly(A) RNA Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Bipolar disorder and major depressive disorder (combined) ( 20351715)
Protein-Protein Interactions		11 interactors: AKT1 DDX39B IL7R LEF1 MAGOH NXF1 RUNX2 THOC1 THOC6 THOC7 UPF3A	13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77
Entrez ID		10189	9984
HPRD ID		09168	09498
Ensembl ID		ENSG00000183684	ENSG00000079134
Uniprot IDs		E9PB61 Q86V81	Q96FV9
PDB IDs		3ULH	1WXP
Enriched GO Terms of Interacting Partners?		MRNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Viral MRNA Export From Host Cell Nucleus Nuclear Export Cytoplasmic Transport Intracellular Transport Of Virus Intracellular Transport Gene Expression MRNA Metabolic Process RNA Splicing Establishment Of Localization In Cell Regulation Of Cell Cycle Checkpoint MRNA Processing Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Gene Expression Viral Life Cycle Cellular Localization Viral Process RNA Processing Regulation Of DNA Damage Checkpoint RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Differentiation T Cell Differentiation Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Adaptive Immune Response B Cell Proliferation Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Activation Regulation Of Translation Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Aggregation T Cell Activation Ossification Lymphocyte Aggregation Leukocyte Aggregation	RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport
Tagcloud ?		ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet	biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Difference) ?		ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet	biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Intersection) ?		export