CORO7 and WASL

Number of citations of the paper that reports this interaction (PubMedID 27143109)
48

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CORO7	WASL
Description		coronin 7	WASP like actin nucleation promoting factor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding	Actin Binding Protein Binding GTPase Regulator Activity
	Biological Process	Golgi To Endosome Transport Actin Filament Organization Golgi Organization Protein Transport Cell Migration Establishment Of Cell Polarity Actin Filament Polymerization Positive Regulation Of Hippo Signaling	Vesicle Budding From Membrane Actin Filament Organization Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Actin Cytoskeleton Organization Actin Filament Polymerization Vesicle Transport Along Actin Filament Protein-containing Complex Localization Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Dendritic Spine Morphogenesis Protein-containing Complex Assembly Regulation Of Postsynapse Organization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Eosinophil count ( 32888494) Erectile dysfunction ( 30583798) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Lymphocyte count ( 32888494) Schizophrenia ( 28991256) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 30389748 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Platelet count ( 22139419 27863252) Plateletcrit ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		9 interacting genes: ACTB AP1M1 AP2M1 EPS15 KLHL20 SRC TOB1 WASL ZRANB1	62 interacting genes: ABI2 ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 ARPC4 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITCH ITGB1BP2 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD OSTF1 PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOQ RIPPLY3 RNF8 RPL7AP66 SDCBP SH3GL3 SH3RF1 SNX9 SORBS2 SRC TNNT3 TRIP10 UBASH3A UBASH3B VASP VIPR1 WIPF1 WIPF2 WIPF3 WWP1 ZNF395
Entrez ID		79585	8976
HPRD ID		07975	05448
Ensembl ID		ENSG00000262246	ENSG00000106299
Uniprot IDs		P57737	O00401
PDB IDs			2FF3 2LNH 2VCP 4CC2 4CC7 9DLX
Enriched GO Terms of Interacting Partners?		Organelle Organization Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Endocytosis Vesicle Organization AP-2 Adaptor Complex Clathrin Adaptor Complex Golgi To Endosome Transport Cellular Component Assembly Clathrin Adaptor Activity Regulation Of Protein Localization Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Vesicle Budding From Membrane Intracellular Transport Polyubiquitin Modification-dependent Protein Binding Actin Cytoskeleton Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cytosol Receptor Internalization Cellular Localization Clathrin-coated Pit Establishment Of Localization In Cell Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Type II Interferon Binding Endocytic Vesicle Membrane Actin Cytoskeleton Organization Clathrin-coated Vesicle Synapse Actin Filament Actin Filament-based Process Intracellular Protein Localization Regulation Of Norepinephrine Uptake Vesicle-mediated Transport In Synapse Negative Regulation Of Membrane Tubulation Protein K33-linked Ubiquitination Protein Deubiquitination Post-Golgi Vesicle-mediated Transport Transporter Regulator Activity Protein Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Protein Localization To Plasma Membrane Symbiont Entry Into Host Cell Protein Modification By Small Protein Removal	Endocytosis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Import Into Cell Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Cytoplasm Cytosol Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Profilin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Endocytosis Positive Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport Regulation Of Cell Projection Organization Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Size Cytoskeletal Anchor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Focal Adhesion Regulation Of Cell Projection Assembly Cytoskeleton Plasma Membrane Tubulation Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Proline-rich Region Binding Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome SH3 Domain Binding Regulation Of Vesicle-mediated Transport Actin Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
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