ARPC3 and WASHC4

		ARPC3	WASHC4
Description		actin related protein 2/3 complex subunit 3	WASH complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome	Nucleoplasm Endosome Early Endosome BLOC-1 Complex Early Endosome Membrane WASH Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding
	Biological Process	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus	Endosome Organization Protein Transport Endosomal Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cognition Neuromuscular Process Regulation Of Protein Complex Stability Nuclear Envelope Budding Endolysosomal Toll-like Receptor Signaling Pathway
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	4 interacting genes: DSCAM MTNR1A SMAD2 WASHC1
Entrez ID		10094	23325
HPRD ID		09175	13829
Ensembl ID		ENSG00000111229	ENSG00000136051
Uniprot IDs		O15145	A0A087X256 B7ZKT9 Q2M389
PDB IDs		6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break	Actin Nucleation Arp2/3 Complex-mediated Actin Nucleation
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