CDH11 and CDH2

Number of citations of the paper that reports this interaction (PMID 14625392)
36

Data Source:
HPRD (in vivo)

		CDH11	CDH2
Gene Name		cadherin 11, type 2, OB-cadherin (osteoblast)	cadherin 2, type 1, N-cadherin (neuronal)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Fascia Adherens Focal Adhesion Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Catenin Complex Lamellipodium Synapse Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Alpha-catenin Binding Gamma-catenin Binding
	Biological Process	Skeletal System Development Ossification Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Corticospinal Tract Morphogenesis Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glial Cell Differentiation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Cell Junction Assembly Adherens Junction Organization Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization Blood Vessel Morphogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance
Pathways		Cell junction organization Cell-cell junction organization Adherens junctions interactions	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Adherens junctions interactions
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Temperament (bipolar disorder) ( 22365631) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		2 interactors: CDH2 CTNNB1	22 interactors: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1
Entrez ID		1009	1000
HPRD ID		08960	00226
Ensembl ID			ENSG00000170558
Uniprot IDs		H3BUU9 P55287	A8MWK3 P19022
PDB IDs
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Positive Regulation Of Muscle Cell Differentiation Stem Cell Maintenance Regulation Of Muscle Cell Differentiation Glial Cell Differentiation Cell Junction Assembly Cell-cell Junction Organization Regulation Of Canonical Wnt Signaling Pathway Gliogenesis Stem Cell Development Schwann Cell Proliferation Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Wnt Signaling Pathway Stem Cell Differentiation Muscle Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Cell-cell Adhesion Mediated By Cadherin Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Determination Of Dorsal Identity Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Lung Induction Blood Vessel Morphogenesis Positive Regulation Of MAPK Cascade Central Nervous System Vasculogenesis Trachea Formation Cellular Response To Indole-3-methanol Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Muscle Structure Development Blood Vessel Development Single Organismal Cell-cell Adhesion Vasculature Development Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Branching Involved In Lung Morphogenesis Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of MAPK Cascade	Cellular Response To Indole-3-methanol Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cell Adhesion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Multicellular Organismal Development Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Anatomical Structure Morphogenesis Cellular Response To Organonitrogen Compound Regulation Of Cell Differentiation Single Organismal Cell-cell Adhesion Developmental Process Response To Organonitrogen Compound Cellular Response To Stimulus Cell Differentiation Anatomical Structure Development Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Muscle Cell Differentiation Response To Stimulus Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glutamate Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Platelet Activation Neuron-neuron Synaptic Transmission Embryonic Digit Morphogenesis Regulation Of Cell Morphogenesis Regulation Of Neural Precursor Cell Proliferation Locomotion Regulation Of Intracellular Signal Transduction Epithelial Cell-cell Adhesion Cell-cell Junction Assembly Enzyme Linked Receptor Protein Signaling Pathway Axon Development Cell-cell Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Homeostatic Process Cellular Component Assembly Protein Heterooligomerization Regulation Of Cell Fate Specification Cellular Response To Peptide Hormone Stimulus Muscle Cell Differentiation Regulation Of MAPK Cascade
Tagcloud ?		1e7 alp autologous bmp2 bony cite exponential fgf2 flask hspa5 igf1 int lef1 morphogenetic osteoblastic osteoblasts picture postn res runx2 smad subtle taqman timely tnfrsf11b transcribed und wingless wnt5a	bioinformatics blotting cadherin downregulating embedded expressions fixed formalin igf1r immunohistochemistry lentiviruses luciferase metastasis mir os osteosarcoma paraffin paraformalin partially predicted probably promising prove quantitative real reporter sosp transfected u2
Tagcloud (Difference) ?		1e7 alp autologous bmp2 bony cite exponential fgf2 flask hspa5 igf1 int lef1 morphogenetic osteoblastic osteoblasts picture postn res runx2 smad subtle taqman timely tnfrsf11b transcribed und wingless wnt5a	bioinformatics blotting cadherin downregulating embedded expressions fixed formalin igf1r immunohistochemistry lentiviruses luciferase metastasis mir os osteosarcoma paraffin paraformalin partially predicted probably promising prove quantitative real reporter sosp transfected u2
Tagcloud (Intersection) ?