CDH11 and CTNND1

Number of citations of the paper that reports this interaction (PubMedID 25466890)
49

Data Source:
BioGRID (pull down)

		CDH11	CTNND1
Description		cadherin 11	catenin delta 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Catenin Complex Midbody Ciliary Basal Body Extracellular Exosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding	Signaling Receptor Binding Protein Binding Phosphatase Inhibitor Activity Phosphatase Binding Cadherin Binding Cell-cell Adhesion Mediator Activity Protein Sequestering Activity
	Biological Process	Cell Morphogenesis Skeletal System Development Ossification Aortic Valve Formation Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Corticospinal Tract Morphogenesis Negative Regulation Of Cell Migration Cell-substrate Adhesion Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Negative Regulation Of D-glucose Transmembrane Transport Wnt Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Intracellular Signal Transduction D-glucose Transmembrane Transport Negative Regulation Of Blood Vessel Branching
Pathways		Adherens junctions interactions Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 function Regulation of CDH11 function CDH11 homotypic and heterotypic interactions	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Drugs		Celecoxib
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 26252872) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Deep white matter hyperintensities ( 32517579) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) High density lipoprotein cholesterol levels ( 33339817) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lung cancer in never smokers ( 28604730) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Schizophrenia ( 28991256) Systolic blood pressure ( 27841878) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: CDH2 CTNNB1 CTNND1 MTNR1B	36 interacting genes: ACTA1 APP CDH1 CDH11 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR EIF4A3 EIF4G3 ERBIN FER GRIK2 GSK3B JUP KCTD6 MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RNF26 RPS6KA3 SMURF1 SNCA SRC SUMO2 WEE2-AS1 YWHAG ZBTB33
Entrez ID		1009	1500
HPRD ID		08960	03026
Ensembl ID		ENSG00000140937	ENSG00000198561
Uniprot IDs		H3BUU9 P55287	O60716
PDB IDs			3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Catenin Complex Cell-cell Adhesion Mediated By Cadherin Detection Of Muscle Stretch Fascia Adherens Regulation Of Blood Vessel Branching Alpha-catenin Binding Synaptic Vesicle Clustering Adherens Junction Cell-cell Junction Regulation Of Protein Localization Apicolateral Plasma Membrane Response To Muscle Stretch Cadherin Binding Negative Regulation Of Signal Transduction Anchoring Junction Detection Of Mechanical Stimulus Negative Regulation Of Cell Communication Adherens Junction Organization Intercalated Disc Negative Regulation Of Signaling Regulation Of Morphogenesis Of A Branching Structure Phosphatase Binding Regulation Of Transport Cell-cell Adhesion Regulation Of Morphogenesis Of An Epithelium Apical Part Of Cell Regulation Of Neural Precursor Cell Proliferation Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Muscle Cell Differentiation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Stem Cell Population Maintenance Vesicle Localization Detection Of Abiotic Stimulus Maintenance Of Cell Number Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synaptic Vesicle Clustering Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Vasculature Development Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex	Cadherin Binding Cell Adhesion Cell Junction Organization Regulation Of Multicellular Organismal Process Cell Junction Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Beta-catenin Binding Regulation Of Signal Transduction Regulation Of Locomotion Cell Junction Assembly Negative Regulation Of Signaling Negative Regulation Of Cell Communication Adherens Junction Cell-cell Adhesion Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Postsynapse Adherens Junction Organization Plasma Membrane Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Cell Migration Cell-cell Junction Assembly Regulation Of Cell Motility Cell-cell Junction Positive Regulation Of Metabolic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Locomotion Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cell-cell Junction Organization Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Positive Regulation Of Cell Migration Developmental Process Glutamatergic Synapse Regulation Of Metabolic Process Regulation Of Synaptic Plasticity Epidermal Growth Factor Receptor Signaling Pathway
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