CDH11

Description		cadherin 11
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Skeletal System Development Ossification Aortic Valve Formation Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Corticospinal Tract Morphogenesis Negative Regulation Of Cell Migration Cell-substrate Adhesion Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Cell-cell Adhesion
Pathways		Adherens junctions interactions Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 function Regulation of CDH11 function CDH11 homotypic and heterotypic interactions
Drugs		Celecoxib
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 26252872) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Deep white matter hyperintensities ( 32517579) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) High density lipoprotein cholesterol levels ( 33339817) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lung cancer in never smokers ( 28604730) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Schizophrenia ( 28991256) Systolic blood pressure ( 27841878) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		4 interacting genes: CDH2 CTNNB1 CTNND1 MTNR1B
Entrez ID		1009
HPRD ID		08960
Ensembl ID		ENSG00000140937
Uniprot IDs		H3BUU9 P55287
PDB IDs
Enriched GO Terms of Interacting Partners?		Catenin Complex Cell-cell Adhesion Mediated By Cadherin Detection Of Muscle Stretch Fascia Adherens Regulation Of Blood Vessel Branching Alpha-catenin Binding Synaptic Vesicle Clustering Adherens Junction Cell-cell Junction Regulation Of Protein Localization Apicolateral Plasma Membrane Response To Muscle Stretch Cadherin Binding Negative Regulation Of Signal Transduction Anchoring Junction Detection Of Mechanical Stimulus Negative Regulation Of Cell Communication Adherens Junction Organization Intercalated Disc Negative Regulation Of Signaling Regulation Of Morphogenesis Of A Branching Structure Phosphatase Binding Regulation Of Transport Cell-cell Adhesion Regulation Of Morphogenesis Of An Epithelium Apical Part Of Cell Regulation Of Neural Precursor Cell Proliferation Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Muscle Cell Differentiation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Stem Cell Population Maintenance Vesicle Localization Detection Of Abiotic Stimulus Maintenance Of Cell Number Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synaptic Vesicle Clustering Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Vasculature Development Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex
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