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CERT1 and CBS
Number of citations of the paper that reports this interaction (PubMedID
19447967
)
24
Data Source:
BioGRID
(two hybrid)
CERT1
CBS
Description
ceramide transporter 1
cystathionine beta-synthase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Lipid Binding
Kinase Activity
Identical Protein Binding
Phosphatidylinositol-4-phosphate Binding
Ceramide Binding
Ceramide Transfer Activity
Ceramide 1-phosphate Binding
Ceramide 1-phosphate Transfer Activity
Catalytic Activity
Cystathionine Beta-synthase Activity
Protein Binding
Lyase Activity
Oxygen Binding
Enzyme Binding
Heme Binding
Pyridoxal Phosphate Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Nitrite Reductase (NO-forming) Activity
Carbon Monoxide Binding
Nitric Oxide Binding
Modified Amino Acid Binding
S-adenosyl-L-methionine Binding
Biological Process
Cell Morphogenesis
In Utero Embryonic Development
Heart Morphogenesis
Ceramide Metabolic Process
Lipid Transport
Muscle Contraction
Immune Response
Mitochondrion Organization
Endoplasmic Reticulum Organization
Signal Transduction
Cell Population Proliferation
Response To Endoplasmic Reticulum Stress
ER To Golgi Ceramide Transport
Ceramide Transport
Lipid Homeostasis
Intermembrane Lipid Transfer
Intermembrane Sphingolipid Transfer
Ceramide 1-phosphate Transport
Endochondral Ossification
Blood Vessel Remodeling
Cysteine Metabolic Process
Cysteine Biosynthetic Process From Serine
L-serine Metabolic Process
L-serine Catabolic Process
Superoxide Metabolic Process
Amino Acid Biosynthetic Process
Serine Family Amino Acid Metabolic Process
Regulation Of Nitric Oxide Mediated Signal Transduction
Cysteine Biosynthetic Process Via Cystathionine
Cysteine Biosynthetic Process
Transsulfuration
L-cysteine Catabolic Process
Cerebellum Morphogenesis
Response To Nutrient Levels
DNA Protection
Negative Regulation Of Apoptotic Process
Homocysteine Catabolic Process
Sulfur Compound Biosynthetic Process
Regulation Of JNK Cascade
Homocysteine Metabolic Process
Response To Folic Acid
Maternal Process Involved In Female Pregnancy
Cartilage Development Involved In Endochondral Bone Morphogenesis
Hydrogen Sulfide Biosynthetic Process
Cellular Response To Hypoxia
Blood Vessel Diameter Maintenance
Pathways
Cysteine formation from homocysteine
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs
Pyridoxal phosphate
Ademetionine
Serine
Cysteine
Diseases
Homocystinuria
GWAS
Blood and toenail selenium levels (
25343990
)
Blood trace element (Se levels) (
23720494
)
Homocysteine levels (
20031578
23824729
)
Neutrophil count (
32888494
)
Obesity-related traits (
23251661
)
Plasma homocysteine levels (post-methionine load test) (
24651765
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Serum metabolite levels (
33031748
)
Interacting Genes
18 interacting genes:
ACTL8
AQP2
ARL6IP1
BSND
CBS
COL4A3
CSNK1G2
FTSJ1
ITGB3BP
MINAR1
PM20D2
POM121
REEP6
RTN3
RTN4
SMU1
STX2
TGM2
35 interacting genes:
ATRX
CBX4
CERT1
DAXX
EHHADH
FAF1
FXR1
FXR2
HGS
HID1
HIPK1
HTT
NTAQ1
PAX6
PIAS1
PIAS2
PIAS3
PIN1
PRKAG1
PRKAR1A
PSMA1
RANBP9
SATB1
SLF2
SMARCAD1
SNCA
SNRNP70
UBASH3A
UBE2I
UGP2
VTA1
ZDHHC17
ZMYM5
ZNF181
ZNF451
Entrez ID
10087
875
HPRD ID
05246
01994
Ensembl ID
ENSG00000113163
ENSG00000160200
Uniprot IDs
A0A2R8Y7C5
Q9Y5P4
B7Z2D6
P35520
PDB IDs
2E3M
2E3N
2E3O
2E3P
2E3Q
2E3R
2E3S
2RSG
2Z9Y
2Z9Z
3H3Q
3H3R
3H3S
3H3T
4HHV
5JJD
5ZYG
5ZYH
5ZYI
5ZYJ
5ZYK
5ZYL
5ZYM
6IEZ
6IF0
6J0O
6J81
1JBQ
1M54
4COO
4L0D
4L27
4L28
4L3V
4PCU
4UUU
5MMS
7QGT
8S5H
8S5I
8S5J
8S5K
8S5L
8S5M
8STW
Enriched GO Terms of Interacting Partners
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Endoplasmic Reticulum Tubular Network Formation
Endoplasmic Reticulum Tubular Network Membrane Organization
Endoplasmic Reticulum Organization
Endoplasmic Reticulum Membrane Organization
Endoplasmic Reticulum Tubular Network Organization
S-adenosyl-L-methionine Binding
Endoplasmic Reticulum Tubular Network
Regulation Of Vasculature Development
Regulation Of Angiogenesis
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Amyloid-beta Formation
Endoplasmic Reticulum
Peptide Dopaminyltransferase Activity
Histone Serotonyltransferase Activity
Peptide Histaminyltransferase Activity
Protein-glutamine Glutaminase Activity
Peptide Noradrenalinyltransferase Activity
Peptide Serotonyltransferase Activity
Histone Dopaminyltransferase Activity
Regulation Of Amyloid-beta Formation
TRNA (guanosine(34)-2'-O)-methyltransferase Activity
Negative Regulation Of Vasculogenesis
Positive Regulation Of ERBB3 Signaling Pathway
Cell Adhesion Involved In Sprouting Angiogenesis
Para-aminobenzoyl-glutamate Hydrolase Activity
Regulation Of Amyloid Precursor Protein Catabolic Process
Lumenal Side Of Membrane
Glycerol Transmembrane Transporter Activity
Basolateral Plasma Membrane
Cysteine Biosynthetic Process From Serine
Cystathionine Beta-synthase Activity
Apoptotic Process
Protein Deamination
Wobble Position Ribose Methylation
TRNA 2'-O-methyltransferase Activity
Folic Acid Catabolic Process
Cell Death
Programmed Cell Death
PML Body
Protein Sumoylation
SUMO Ligase Activity
SUMO Transferase Activity
Postsynaptic Cytosol
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Presynaptic Cytosol
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nuclear Speck
Regulation Of Metabolic Process
Ubiquitin Protein Ligase Binding
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Negative Regulation Of RNA Metabolic Process
Enzyme Binding
Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Protein Modification Process
Transcription Corepressor Activity
Phosphoprotein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Metabolic Process
Macromolecule Metabolic Process
CAMP-dependent Protein Kinase Regulator Activity
Nuclear Body
Protein Domain Specific Binding
Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Iris Morphogenesis
Regulation Of Chaperone-mediated Autophagy
Glutamatergic Synapse
Cytosol
Regulation Of Protein Metabolic Process
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
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Tagcloud (Intersection)
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