PCAT1 and FAF2

Number of citations of the paper that reports this interaction (PubMedID 31903119)
55

Data Source:
BioGRID (unspecified method)

		PCAT1	FAF2
Description		prostate cancer associated transcript 1	Fas associated factor family member 2
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen
	Molecular Function		Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity
	Biological Process		Response To Unfolded Protein Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Stress Granule Disassembly ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neutrophil degranulation RHOA GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 25673413) Heel bone mineral density ( 28869591 30598549) Intracranial aneurysm ( 29531279) Lung cancer in never smokers ( 28604730)	Cirrhosis (alcohol related) ( 32853455)
Interacting Genes		13 interacting genes: AAMP CASD1 FAF2 FILNC1 GJA10 GRWD1 HNRNPH1 NAV3 PCCB PCLO PDIA3 RPL11 TUFM	13 interacting genes: ELAVL1 FAF1 FAS MAP3K1 OGT PCAT1 PNPLA2 PSMD2 SMURF1 UBC UBE2D1 UBE3A VASP
Entrez ID		100750225	23197
HPRD ID			16870
Ensembl ID		ENSG00000253438	ENSG00000113194
Uniprot IDs			Q96CS3
PDB IDs			2DAM
Enriched GO Terms of Interacting Partners?			Fas Signaling Pathway Modification-dependent Protein Catabolic Process CD95 Death-inducing Signaling Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Cytosol Catabolic Process Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Regulation Of TOR Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Autophagosome Size Positive Regulation Of Catabolic Process Glutamatergic Synapse Protein Metabolic Process Intracellular Chemical Homeostasis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Proteasome Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Protein Ubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Polyubiquitination Cellular Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Stem Cell Population Maintenance Proteasome Storage Granule Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Signal Transduction
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