MTHFD1

Description		methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Catalytic Activity Formate-tetrahydrofolate Ligase Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding Oxidoreductase Activity Hydrolase Activity Ligase Activity
	Biological Process	Neutrophil Homeostasis Neural Tube Closure Purine Nucleotide Biosynthetic Process Methionine Metabolic Process One-carbon Metabolic Process Heart Development Serine Family Amino Acid Metabolic Process Methionine Biosynthetic Process Purine Ribonucleotide Biosynthetic Process 10-formyltetrahydrofolate Biosynthetic Process Transsulfuration Tetrahydrofolate Interconversion Folic Acid Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Somite Development
Pathways		Metabolism of folate and pterines
Drugs		Tetrahydrofolic acid NADH LY374571 Nicotinamide adenine dinucleotide phosphate LY249543
Diseases		Spina bifida
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive performance ( 19734545) Longevity ( 30294719) Lymphocyte count ( 27863252)
Interacting Genes		5 interacting genes: CEBPA DUX4 ESR1 SENP3 SUMO2
Entrez ID		4522
HPRD ID		01403
Ensembl ID		ENSG00000100714
Uniprot IDs		F5H2F4 P11586
PDB IDs		1A4I 1DIA 1DIB 1DIG 6ECP 6ECQ 6ECR 9ISE 9ISL 9ISR 9ITD 9IUO
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 Positive Regulation Of RNA Metabolic Process C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process White Fat Cell Proliferation Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Proteolysis Nucleolus Response To Phenylpropanoid Regulation Of Primary Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Steroid Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Branching Involved In Prostate Gland Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation DeSUMOylase Activity Negative Regulation Of G0 To G1 Transition Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Fat Cell Proliferation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Protein Desumoylation
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