MTHFD1 and SENP3

Number of citations of the paper that reports this interaction (PubMedID 28265077)
59

Data Source:
BioGRID (enzymatic study)

		MTHFD1	SENP3
Description		methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	SUMO specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body MLL1 Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Formate-tetrahydrofolate Ligase Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding Oxidoreductase Activity Hydrolase Activity Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity
	Biological Process	Neutrophil Homeostasis Neural Tube Closure Purine Nucleotide Biosynthetic Process Methionine Metabolic Process One-carbon Metabolic Process Heart Development Serine Family Amino Acid Metabolic Process Methionine Biosynthetic Process Purine Ribonucleotide Biosynthetic Process 10-formyltetrahydrofolate Biosynthetic Process Transsulfuration Tetrahydrofolate Interconversion Folic Acid Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Somite Development	Proteolysis Protein Desumoylation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Metabolism of folate and pterines	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Tetrahydrofolic acid NADH LY374571 Nicotinamide adenine dinucleotide phosphate LY249543
Diseases		Spina bifida
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive performance ( 19734545) Longevity ( 30294719) Lymphocyte count ( 27863252)	Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: CEBPA DUX4 ESR1 SENP3 SUMO2	20 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MED25 MTHFD1 NPM1 PARP1 PELP1 SUMO2 TRIM54 TRIM63 USP15 USP21
Entrez ID		4522	26168
HPRD ID		01403	08339
Ensembl ID		ENSG00000100714	ENSG00000161956
Uniprot IDs		F5H2F4 P11586	Q9H4L4
PDB IDs		1A4I 1DIA 1DIB 1DIG 6ECP 6ECQ 6ECR 9ISE 9ISL 9ISR 9ITD 9IUO
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 Positive Regulation Of RNA Metabolic Process C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process White Fat Cell Proliferation Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Proteolysis Nucleolus Response To Phenylpropanoid Regulation Of Primary Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Steroid Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Branching Involved In Prostate Gland Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation DeSUMOylase Activity Negative Regulation Of G0 To G1 Transition Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Fat Cell Proliferation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Protein Desumoylation	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Transcription Regulator Complex Nucleoplasm Regulation Of Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Protein-DNA Complex Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Organelle Organization Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Metaphase Plate Congression Cellular Response To UV Regulation Of Fibroblast Proliferation Regulation Of Muscle System Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Chromatin Organization Regulation Of Cellular Response To Stress Negative Regulation Of Small Molecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle G2/M Phase Transition Ubiquitin Protein Ligase Binding Negative Regulation Of ATP Metabolic Process Regulation Of Phosphorus Metabolic Process Mononuclear Cell Differentiation Regulation Of Gene Expression Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process
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