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PLA2G4B and CASP7
Number of citations of the paper that reports this interaction (PMID
9875225
)
6
Data Source:
BioGRID
(enzymatic study)
PLA2G4B
CASP7
Gene Name
phospholipase A2, group IVB (cytosolic)
caspase 7, apoptosis-related cysteine peptidase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Mitochondrial Inner Membrane
Cytosol
Early Endosome Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Lysophospholipase Activity
Calcium Ion Binding
Calcium-dependent Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Peptidase Activity
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Inflammatory Response
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Parturition
Arachidonic Acid Metabolic Process
Calcium-mediated Signaling
Endoplasmic Reticulum Unfolded Protein Response
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cellular Protein Metabolic Process
Small Molecule Metabolic Process
Glycerophospholipid Biosynthetic Process
Glycerophospholipid Catabolic Process
Proteolysis
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Pathways
Acyl chain remodelling of PE
Hydrolysis of LPC
Synthesis of PA
Metabolism of lipids and lipoproteins
Glycerophospholipid biosynthesis
Acyl chain remodelling of PS
XBP1(S) activates chaperone genes
Acyl chain remodelling of PG
IRE1alpha activates chaperones
Phospholipid metabolism
Acyl chain remodelling of PC
Unfolded Protein Response (UPR)
Activation of caspases through apoptosome-mediated cleavage
Apoptotic cleavage of cellular proteins
Apoptotic factor-mediated response
SMAC binds to IAPs
Apoptotic execution phase
Programmed Cell Death
SMAC-mediated dissociation of IAP:caspase complexes
Cytochrome c-mediated apoptotic response
SMAC-mediated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Intrinsic Pathway for Apoptosis
Drugs
Fica
Diseases
GWAS
Vitiligo (
22561518
)
Protein-Protein Interactions
4 interactors:
CASP1
CASP3
CASP7
CASP8
60 interactors:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HSPA5
KRT18
LYN
MAPT
MAX
MEF2A
MEF2D
NEDD4
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
UBE4B
VIM
XIAP
Entrez ID
100137049
840
HPRD ID
03457
Ensembl ID
ENSG00000243708
ENSG00000165806
Uniprot IDs
P0C869
B4DWA2
P55210
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1MIA
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
Enriched GO Terms of Interacting Partners
?
Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Zymogen Activation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Peptidase Activity
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Protein Processing
Positive Regulation Of Proteolysis
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Endopeptidase Activity
Regulation Of Peptidase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Intrinsic Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Hydrolase Activity
Cell Death
Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Apoptotic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Proteolysis
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Mechanical Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Response To Tumor Necrosis Factor
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Mitochondrial Depolarization
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Abiotic Stimulus
Intracellular Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-1 Alpha Secretion
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Negative Regulation Of Apoptotic Process
Execution Phase Of Apoptosis
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Response To Stress
Response To Stimulus
Regulation Of Cellular Component Organization
Cell Communication
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Signaling
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cellular Process
Regulation Of Signaling
Myeloid Cell Differentiation
System Development
Regulation Of Metabolic Process
Cellular Response To Organic Substance
Viral Process
Regulation Of Proteolysis
Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Endopeptidase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Peptidase Activity
Anatomical Structure Development
Enzyme Linked Receptor Protein Signaling Pathway
Response To Organic Substance
Multicellular Organismal Development
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
balb
casp3
casp8
caspase3
closure
d10
d5
d7
dermal
execution
extrinsic
fasr
harvested
healing
innovation
intersect
intrinsic
mechanistically
mucosal
preprogrammed
punch
scarring
therapeutics
tnfrsf1b
tongue
tradd
trp53
wound
wounds
Tagcloud (Difference)
?
balb
casp3
casp8
caspase3
closure
d10
d5
d7
dermal
execution
extrinsic
fasr
harvested
healing
innovation
intersect
intrinsic
mechanistically
mucosal
preprogrammed
punch
scarring
therapeutics
tnfrsf1b
tongue
tradd
trp53
wound
wounds
Tagcloud (Intersection)
?