PLA2G4B and CASP7

Number of citations of the paper that reports this interaction (PubMedID 9875225)
0

Data Source:
BioGRID (enzymatic study)

		PLA2G4B	CASP7
Description		phospholipase A2 group IVB	caspase 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endosome Cytosol Membrane Early Endosome Membrane Mitochondrial Membrane	Fibrillar Center Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A1 Activity Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	RNA Binding Catalytic Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Inflammatory Response Parturition Phospholipid Catabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Calcium-mediated Signaling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Glycerophospholipid Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Regulation Of Transcription By RNA Polymerase II Proteolysis Apoptotic Process Heart Development Response To UV Protein Processing Protein Catabolic Process Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Ceramide Biosynthetic Process Striated Muscle Cell Differentiation Neuron Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Lymphocyte Apoptotic Process Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis Positive Regulation Of Plasma Membrane Repair
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA XBP1(S) activates chaperone genes	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs			Fica Emricasan Incadronic acid
Diseases
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 22561518 27723757)
Interacting Genes		5 interacting genes: CASP1 CASP3 CASP7 CASP8 HRAS	63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HNRNPH1 HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A TRIM25 UBE4B VIM XIAP
Entrez ID		100137049	840
HPRD ID			03457
Ensembl ID		ENSG00000243708	ENSG00000165806
Uniprot IDs		P0C869	A0A0A0MRL7 B4DWA2 P55210
PDB IDs			1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z 7WZS 8DGZ 8DJ3
Enriched GO Terms of Interacting Partners?		Pyroptotic Inflammatory Response Cysteine-type Endopeptidase Activity Protein Poly-ADP-ribosylation Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Protein Processing Regulation Of Neuron Apoptotic Process Cell Death Protein Maturation Response To Molecule Of Bacterial Origin Apoptotic Process Response To Lipopolysaccharide Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Cellular Response To Staurosporine Response To Anesthetic Death-inducing Signaling Complex Peptidase Activity Response To External Biotic Stimulus Positive Regulation Of Pyroptotic Inflammatory Response Neuron Apoptotic Process Defense Response Response To Cobalt Ion Fibroblast Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Inflammatory Response Interleukin-18-mediated Signaling Pathway Hydrolase Activity Death Receptor Binding Positive Regulation Of Inflammatory Response Aspartic-type Endopeptidase Activity Response To Lipid Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Plasma Membrane Repair Heart Development Cellular Response To Alkaloid Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Ceramide Biosynthetic Process Proteolysis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Radiation Positive Regulation Of Interleukin-1 Production	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Cytosol Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleus Cytoplasm Intracellular Signal Transduction Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Cellular Component Organization Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Execution Phase Of Apoptosis Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cellular Response To Stress Myeloid Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Regulation Of Cell Communication Regulation Of Necroptotic Process Protein Metabolic Process Cysteine-type Endopeptidase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Protein Maturation Regulation Of Programmed Necrotic Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Protein Processing
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