PLA2G4B

Gene Name		phospholipase A2, group IVB (cytosolic)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Mitochondrial Inner Membrane Cytosol Early Endosome Membrane
	Molecular Function	Lysophospholipase Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Inflammatory Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Parturition Arachidonic Acid Metabolic Process Calcium-mediated Signaling Endoplasmic Reticulum Unfolded Protein Response Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cellular Protein Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Glycerophospholipid Catabolic Process
Pathways		Acyl chain remodelling of PE Hydrolysis of LPC Synthesis of PA Metabolism of lipids and lipoproteins Glycerophospholipid biosynthesis Acyl chain remodelling of PS XBP1(S) activates chaperone genes Acyl chain remodelling of PG IRE1alpha activates chaperones Phospholipid metabolism Acyl chain remodelling of PC Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CASP1 CASP3 CASP7 CASP8
Entrez ID		100137049
HPRD ID
Ensembl ID		ENSG00000243708
Uniprot IDs		P0C869
PDB IDs
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Positive Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Response To Mechanical Stimulus Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Response To Tumor Necrosis Factor Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Abiotic Stimulus Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion
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