PLA2G4B

Description		phospholipase A2 group IVB
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endosome Cytosol Membrane Early Endosome Membrane Mitochondrial Membrane
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Phospholipase A1 Activity Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Inflammatory Response Parturition Phospholipid Catabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Calcium-mediated Signaling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Glycerophospholipid Catabolic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: CASP1 CASP3 CASP7 CASP8 HRAS
Entrez ID		100137049
HPRD ID
Ensembl ID		ENSG00000243708
Uniprot IDs		P0C869
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyroptotic Inflammatory Response Cysteine-type Endopeptidase Activity Protein Poly-ADP-ribosylation Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Protein Processing Regulation Of Neuron Apoptotic Process Cell Death Protein Maturation Response To Molecule Of Bacterial Origin Apoptotic Process Response To Lipopolysaccharide Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Cellular Response To Staurosporine Response To Anesthetic Death-inducing Signaling Complex Peptidase Activity Response To External Biotic Stimulus Positive Regulation Of Pyroptotic Inflammatory Response Neuron Apoptotic Process Defense Response Response To Cobalt Ion Fibroblast Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Inflammatory Response Interleukin-18-mediated Signaling Pathway Hydrolase Activity Death Receptor Binding Positive Regulation Of Inflammatory Response Aspartic-type Endopeptidase Activity Response To Lipid Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Plasma Membrane Repair Heart Development Cellular Response To Alkaloid Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Ceramide Biosynthetic Process Proteolysis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Radiation Positive Regulation Of Interleukin-1 Production
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