SREBF1 and YY1

Number of citations of the paper that reports this interaction (PMID 10224053)
11

Data Source:
HPRD (in vitro)

		SREBF1	YY1
Gene Name		sterol regulatory element binding transcription factor 1	YY1 transcription factor
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex	Nucleus Transcription Factor Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Protein Complex Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein Dimerization Activity	Four-way Junction DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Rate By Chemical Signal Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Lung Development Positive Regulation Of Histone Deacetylation Response To Food Response To Retinoic Acid Response To Progesterone Response To Glucagon Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Positive Regulation Of Gene Expression Cell Differentiation Cellular Response To UV Response To Prostaglandin F Camera-type Eye Morphogenesis Chromosome Organization
Pathways		RORA activates circadian gene expression
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		35 interactors: AR ATXN1 ATXN1L CDK8 CREBBP ESR1 ESR2 GSK3B HNF4A ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 NR0B1 SIRT1 SMARCD3 SP1 SREBF2 SUMO1 TWIST2 UBE2I YY1 ZBTB7C	52 interactors: APP ATF2 ATF6 ATF7 BAP1 BRCA1 CDKN2A CREB1 CRKL E2F2 E2F3 EED EP300 FKBP1A FKBP3 GRN GTF2I HCFC1 HDAC2 HDAC3 HIST1H4A HOXA11 INO80 KAT2B MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PPIA PSMD9 RAF1 RYBP SAP30 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 UHRF2 YAF2 ZNF232 ZRANB2
Entrez ID		6720	7528
HPRD ID		01701	02482
Ensembl ID		ENSG00000072310
Uniprot IDs		B4DEU6 P36956	P25490
PDB IDs		1AM9	1UBD 1ZNM
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Cellular Response To Heat Regulation Of Cell Differentiation Organ Development Cell Differentiation Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Chromatin Organization Biosynthetic Process Cellular Response To Organic Substance Chromatin Modification Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Process Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Chromosome Organization
Tagcloud ?		aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate	activates activators adenylyl amp cbp clue creb cyclase cyclic depend discuss dissociates e2f1 exactly examples generating homologue implying machinery messenger myb myod neurotransmitter outline phosphorylates pka predisposition superfamily transported
Tagcloud (Difference) ?		aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate	activates activators adenylyl amp cbp clue creb cyclase cyclic depend discuss dissociates e2f1 exactly examples generating homologue implying machinery messenger myb myod neurotransmitter outline phosphorylates pka predisposition superfamily transported
Tagcloud (Intersection) ?