UNG and RPA2

Number of citations of the paper that reports this interaction (PubMedID 9045683)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		UNG	RPA2
Description		uracil DNA glycosylase	replication protein A2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP ATP2A2 CAPN11 CCDC33 CEBPA CRY1 DAO FTH1 KERA P2RY6 PCNA PRDM4 RPA2 RPS20 SEZ6L2 SLC17A7	69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14
Entrez ID		7374	6118
HPRD ID		01881	01566
Ensembl ID		ENSG00000076248	ENSG00000117748
Uniprot IDs		E5KTA5 E5KTA6 P13051	B4DUL2 P15927
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity	DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process
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