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RPA2 and WRN
Number of citations of the paper that reports this interaction (PubMedID
37827155
)
181
Data Source:
BioGRID
(far western blotting, proximity labelling technology)
RPA2
WRN
Description
replication protein A2
WRN RecQ like helicase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Centrosome
Nuclear Speck
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Catalytic Activity
Helicase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Four-way Junction Helicase Activity
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
Manganese Ion Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Protein-containing Complex Binding
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
3'-flap-structured DNA Binding
Catalytic Activity, Acting On DNA
8-hydroxy-2'-deoxyguanosine DNA Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Synthesis Involved In DNA Repair
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Base-excision Repair
Mismatch Repair
Double-strand Break Repair
DNA Recombination
DNA Damage Response
Response To Oxidative Stress
Determination Of Adult Lifespan
Cellular Response To Starvation
Response To UV-C
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Regulation Of Growth Rate
Positive Regulation Of Hydrolase Activity
Telomeric D-loop Disassembly
Cellular Response To Gamma Radiation
Cellular Senescence
Replicative Senescence
T-circle Formation
Positive Regulation Of Strand Invasion
Protein Localization To Nucleolus
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Chronotype (
30696823
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Daytime sleep phenotypes (
27126917
)
Exercise treadmill test traits (
17903301
)
Fasting glucose change (long-term) (
31263163
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Intelligence (MTAG) (
29326435
)
Lifespan (
25918517
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Logical memory (immediate recall) in mild cognitive impairment (
29274321
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
38 interacting genes:
ADRB3
ATM
ATRX
BARD1
BLM
BRCA1
CDKN2A
FEN1
H2AX
HTR5A
LINC03042
MDC1
MDM2
MIB1
PARP1
PCNA
POLB
POLD2
POLK
POLR1C
PRKAR1B
PRKDC
RAD1
RAD51
RAD52
RAD54B
RAD9A
RPA1
RPA2
SUMO1
SUMO2
TERF2
TP53
UBXN8
VCP
WRNIP1
XRCC5
XRCC6
Entrez ID
6118
7486
HPRD ID
01566
05212
Ensembl ID
ENSG00000117748
ENSG00000165392
Uniprot IDs
B4DUL2
P15927
Q14191
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
2AXL
2DGZ
2E1E
2E1F
2FBT
2FBV
2FBX
2FBY
2FC0
3AAF
6TYV
6YHR
7GQS
7GQT
7GQU
7XUT
8PFL
8PFO
8PFP
8YLE
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
DNA Repair
DNA Damage Response
DNA Metabolic Process
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair
Nucleic Acid Metabolic Process
Damaged DNA Binding
Chromosome, Telomeric Region
Response To Radiation
DNA Recombination
Recombinational Repair
Cellular Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Telomere Maintenance
Cellular Response To Ionizing Radiation
Telomere Organization
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Signal Transduction In Response To DNA Damage
Response To Gamma Radiation
Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Chromosome Organization
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of DNA Repair
DNA Binding
Regulation Of Cell Cycle Phase Transition
DNA Biosynthetic Process
Site Of Double-strand Break
Enzyme Binding
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Body
Regulation Of Cell Cycle
DNA Replication
Cellular Response To Gamma Radiation
Protein Localization To Organelle
PML Body
Replication Fork Processing
Protein-containing Complex
Regulation Of DNA Recombination
Negative Regulation Of Mitotic Cell Cycle
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