UNG and KERA

		UNG	KERA
Description		uracil DNA glycosylase	keratocan
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Visual Perception Cornea Development In Camera-type Eye
Pathways			Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	Cornea plana congenita
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Pre-treatment viral load in HIV-1 infection ( 31219150) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		16 interacting genes: APP ATP2A2 CAPN11 CCDC33 CEBPA CRY1 DAO FTH1 KERA P2RY6 PCNA PRDM4 RPA2 RPS20 SEZ6L2 SLC17A7	2 interacting genes: CHMP2A UNG
Entrez ID		7374	11081
HPRD ID		01881	04477
Ensembl ID		ENSG00000076248	ENSG00000139330
Uniprot IDs		E5KTA5 E5KTA6 P13051	O60938
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity	Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal Base-excision Repair, AP Site Formation Single Strand Break Repair Ribosomal Small Subunit Binding Uracil DNA N-glycosylase Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination DNA Modification Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Pyrimidine-containing Compound Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process ESCRT III Complex Multivesicular Body Membrane Negative Regulation Of Centriole Elongation Viral Budding From Plasma Membrane Amphisome Membrane Late Endosome To Lysosome Transport Lysosomal Membrane Organization Vesicle Fusion With Vacuole Kinetochore Microtubule Viral Budding Regulation Of Exosomal Secretion ESCRT III Complex Disassembly Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell ESCRT Complex Disassembly Midbody Abscission Membrane Coat Multivesicular Body-lysosome Fusion Positive Regulation Of Exosomal Secretion Exit From Mitosis Phosphatidylcholine Binding Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Somatic Recombination Of Immunoglobulin Gene Segments Base-excision Repair Late Endosome To Vacuole Transport Deoxyribonucleotide Metabolic Process
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