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RPA2 and SMARCAL1
Number of citations of the paper that reports this interaction (PubMedID
37827155
)
181
Data Source:
BioGRID
(pull down, x-ray crystallography, proximity labelling technology)
RPA2
SMARCAL1
Description
replication protein A2
SNF2 related chromatin remodeling annealing helicase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Site Of Double-strand Break
Nuclear Replication Fork
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
ATP-dependent DNA/DNA Annealing Activity
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Replication Fork Processing
T-circle Formation
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
Drugs
Diseases
Schimke immunoosseous dysplasia
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (
32963231
)
Cortical thickness (MOSTest) (
32665545
)
Extremely high intelligence (
29520040
)
HDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
White matter integrity (fractional anisotropy) (
32358547
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
2 interacting genes:
ACSL3
RPA2
Entrez ID
6118
50485
HPRD ID
01566
05969
Ensembl ID
ENSG00000117748
ENSG00000138375
Uniprot IDs
B4DUL2
P15927
Q9NZC9
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
4MQV
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Medium-chain Fatty Acid-CoA Ligase Activity
Regulation Of Phosphatidylcholine Metabolic Process
Positive Regulation Of Golgi To Plasma Membrane Protein Transport
Very-low-density Lipoprotein Particle Assembly
Arachidonate-CoA Ligase Activity
Regulation Of Golgi To Plasma Membrane Protein Transport
Regulation Of Phosphatidylcholine Biosynthetic Process
Long-chain Fatty Acid Import Into Cell
Palmitoyl-CoA Ligase Activity
Positive Regulation Of Phospholipid Biosynthetic Process
Fatty Acid-CoA Ligase Activity
G-rich Strand Telomeric DNA Binding
Long-chain Fatty Acid-CoA Ligase Activity
Lipid Import Into Cell
DNA Replication Factor A Complex
Mitotic G1 DNA Damage Checkpoint Signaling
Mitotic G1/S Transition Checkpoint Signaling
Regulation Of Phospholipid Biosynthetic Process
Long-chain Fatty-acyl-CoA Biosynthetic Process
Plasma Lipoprotein Particle Assembly
Regulation Of DNA Damage Checkpoint
Protein-lipid Complex Assembly
Long-chain Fatty-acyl-CoA Metabolic Process
Fatty-acyl-CoA Biosynthetic Process
Telomeric DNA Binding
Mismatch Repair
Regulation Of Phospholipid Metabolic Process
Base-excision Repair
Fatty Acid Derivative Biosynthetic Process
Long-chain Fatty Acid Transport
Nucleotide-excision Repair
Peroxisomal Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Damaged DNA Binding
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Protein Localization To Cell Periphery
Fatty Acid Derivative Metabolic Process
Positive Regulation Of Lipid Biosynthetic Process
Sulfur Compound Biosynthetic Process
Lipid Droplet
Long-chain Fatty Acid Metabolic Process
Fatty Acid Transport
Acyl-CoA Metabolic Process
Positive Regulation Of Protein Localization To Membrane
Telomere Maintenance
Protein Phosphatase Binding
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Tagcloud (Difference)
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Tagcloud (Intersection)
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