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RPA2 and EXOSC7
Number of citations of the paper that reports this interaction (PubMedID
37827155
)
181
Data Source:
BioGRID
(two hybrid, proximity labelling technology)
RPA2
EXOSC7
Description
replication protein A2
exosome component 7
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nucleolar Exosome (RNase Complex)
Exoribonuclease Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
3'-5'-RNA Exonuclease Activity
RNA Binding
RNA Exonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
RNA Processing
RNA Catabolic Process
RRNA Catabolic Process
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
TRAMP-dependent TRNA Surveillance Pathway
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Nuclear RNA decay
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Acne (severe) (
24927181
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
30153862
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
47 interacting genes:
ALG13
APP
C1orf35
CCDC59
DIS3
DMRTB1
DPYSL2
DXO
EHMT2
EIF4ENIF1
ESRRG
ESS2
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC8
EXOSC9
HOOK1
IP6K1
KIF24
KRT31
LARP4
MIF
MTREX
PALS2
PRC1
PRPF6
PRRC2B
PTEN
RALYL
RBM22
RBM7
RBPMS
RPA2
RPL21
SETD2
SNRNP48
SNW1
SUPT5H
TFIP11
THOC1
UBE2K
UNKL
VIM
Entrez ID
6118
23016
HPRD ID
01566
09401
Ensembl ID
ENSG00000117748
ENSG00000075914
Uniprot IDs
B4DUL2
P15927
B2RDZ9
Q15024
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
2NN6
6D6Q
6D6R
6H25
9G8M
9G8N
9G8O
9G8P
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Nucleolar Exosome (RNase Complex)
Nuclear MRNA Surveillance
RNA Exonuclease Activity
Nuclear RNA Surveillance
RNA Binding
RNA Surveillance
U4 SnRNA 3'-end Processing
SnRNA Metabolic Process
RNA Catabolic Process
MRNA Metabolic Process
RRNA Catabolic Process
RNA Processing
Poly(A)-dependent SnoRNA 3'-end Processing
Nuclear-transcribed MRNA Catabolic Process
RNA Metabolic Process
SnRNA 3'-end Processing
MRNA Catabolic Process
Nucleobase-containing Compound Catabolic Process
3'-5'-RNA Exonuclease Activity
RRNA Processing
SnRNA Processing
Exoribonuclease Complex
Sno(s)RNA Metabolic Process
RRNA Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
TRNA Surveillance
TRAMP-dependent TRNA Surveillance Pathway
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nucleic Acid Metabolic Process
RNA 3'-end Processing
Nucleoplasm
RRNA 3'-end Processing
TRNA Decay
Nucleobase-containing Compound Metabolic Process
Nucleus
Macromolecule Metabolic Process
Catalytic Step 2 Spliceosome
SnRNA Catabolic Process
CUT Catabolic Process
Macromolecule Catabolic Process
Spliceosomal Complex
DNA Deamination
RNA Splicing
Nucleolus
Negative Regulation Of Gene Expression
MRNA Splicing, Via Spliceosome
Maturation Of 5.8S RRNA
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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