RPA2 and MEN1

Number of citations of the paper that reports this interaction (PubMedID 12509449)
68

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RPA2	MEN1
Description		replication protein A2	menin 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Transcription Repressor Complex Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Four-way Junction DNA Binding Y-form DNA Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Phosphoprotein Binding R-SMAD Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity T-helper 2 Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Urate levels ( 21768215)
Interacting Genes		69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14	31 interacting genes: ANXA1 ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM
Entrez ID		6118	4221
HPRD ID		01566	00564
Ensembl ID		ENSG00000117748	ENSG00000133895
Uniprot IDs		B4DUL2 P15927	A0A5F9ZHS3 A0AA75I0P0 E7EN32 O00255 Q9GZQ5
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6S2K 6WNH 7M4T 7O9T 7O9X 7O9Z 7OA9 7UJ4 8E90 8GPN 8IG0 8VA5 8VA6 9C92 9C93 9C94
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process	Transcription Regulator Complex Nucleoplasm Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Growth Factor Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor Binding Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Enzyme Binding Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription
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