PPM1D and ATP6V1A

		PPM1D	ATP6V1A
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	ATPase H+ transporting V1 subunit A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding ATP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Cellular Iron Ion Homeostasis ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Proton Transmembrane Transport
Pathways		Transcriptional regulation by RUNX2	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Prostate cancer ( 23535732)
Interacting Genes		25 interacting genes: ATP6V1A BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	15 interacting genes: ANXA7 CD200R1L CDC42 CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM
Entrez ID		8493	523
HPRD ID		05482	06120
Ensembl ID		ENSG00000170836	ENSG00000114573
Uniprot IDs		A0A0S2Z4M2 O15297	P38606
PDB IDs			6WLZ 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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