PDZD3 and NLRX1

		PDZD3	NLRX1
Description		PDZ domain containing 3	NLR family member X1
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GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Protein Binding ATP Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways		Intestinal infectious diseases	DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		21 interacting genes: ABCC2 ASAP3 CACNA1S CFTR FCER1G GUCY2C NLRX1 NOMO1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 PDZD3 SARM1 SCN3B TMEM25 TMPRSS4
Entrez ID		79849	79671
HPRD ID		06191	17640
Ensembl ID		ENSG00000172367	ENSG00000160703
Uniprot IDs		B0YJ61 Q86UT5	Q86UT6
PDB IDs		2V90	3UN9
Enriched GO Terms of Interacting Partners?
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