PDZD3 and CACNA1S

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PDZD3	CACNA1S
Description		PDZ domain containing 3	calcium voltage-gated channel subunit alpha1 S
Image
GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine
Pathways		Intestinal infectious diseases	NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS			Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Permanent tooth development ( 21931568) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		21 interacting genes: ABCC2 ASAP3 CACNA1S CFTR FCER1G GUCY2C NLRX1 NOMO1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	10 interacting genes: CCDC106 CYSRT1 KDR MEOX2 PDZD3 REL RIMS2 RYR1 SLC25A17 SRI
Entrez ID		79849	779
HPRD ID		06191	00248
Ensembl ID		ENSG00000172367	ENSG00000081248
Uniprot IDs		B0YJ61 Q86UT5	B1ALM3 Q13698
PDB IDs		2V90	2VAY 6B27
Enriched GO Terms of Interacting Partners?
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