NLRX1 and BUD13

		NLRX1	BUD13
Description		NLR family member X1	BUD13 homolog
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction	Nucleus Nucleoplasm U2-type Spliceosomal Complex RES Complex U2-type Precatalytic Spliceosome
	Molecular Function	Protein Binding ATP Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	MRNA Splicing, Via Spliceosome
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Adventurousness ( 30643258) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cardiovascular risk factors (age interaction) ( 20838585) Coronary artery disease ( 29263402 29212778) Cutaneous squamous cell carcinoma ( 27424798 32041948) Delirium ( 29631748) Disease progression in age-related macular degeneration ( 29346644) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HIV-1 susceptibility ( 21160409) Hypertriglyceridemia ( 31087446 23505323) LDL cholesterol ( 20864672) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid traits ( 24023261) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolic syndrome ( 30382898 21386085) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23823483 31628463) Platelet count ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Red cell distribution width ( 28957414) Response to Vitamin E supplementation ( 22437554) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549 32902719 26763881 30911093 28371326 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 21909109 18193044 20864672 26160806 24886709) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Interacting Genes		9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 PDZD3 SARM1 SCN3B TMEM25 TMPRSS4	4 interacting genes: GPKOW NLRX1 RBMX2 SRPK2
Entrez ID		79671	84811
HPRD ID		17640	11307
Ensembl ID		ENSG00000160703	ENSG00000137656
Uniprot IDs		Q86UT6	Q9BRD0
PDB IDs		3UN9	5Z56 5Z57 5Z58 6FF4 6FF7 7ABI
Enriched GO Terms of Interacting Partners?
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