PDZD3 and GUCY2C

Number of citations of the paper that reports this interaction (PubMedID 11950846)
21

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		PDZD3	GUCY2C
Description		PDZ domain containing 3	guanylate cyclase 2C
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Population Proliferation
Pathways		Intestinal infectious diseases	Digestion Intestinal infectious diseases
Drugs			Linaclotide
Diseases
GWAS
Interacting Genes		21 interacting genes: ABCC2 ASAP3 CACNA1S CFTR FCER1G GUCY2C NLRX1 NOMO1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	3 interacting genes: GUCA2A PDZD3 SRC
Entrez ID		79849	2984
HPRD ID		06191	07529
Ensembl ID		ENSG00000172367	ENSG00000070019
Uniprot IDs		B0YJ61 Q86UT5	P25092
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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