SF1 and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SF1	TRIM69
Description		splicing factor 1	tripartite motif containing 69
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription	Protein Polyubiquitination Apoptotic Process
Pathways		mRNA Splicing - Major Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Artenimol
Diseases
GWAS		Urate levels ( 21768215)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		43 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461	28 interacting genes: APP ASNS ATP5MC1 DVL1 FAM110A FKBP1B HAUS1 HGS IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N ZNF483
Entrez ID		7536	140691
HPRD ID		03306	11518
Ensembl ID		ENSG00000168066	ENSG00000185880
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	H0YL66 Q86WT6
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	4NQJ
Enriched GO Terms of Interacting Partners?
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