TRIM69 and SF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM69	SF1
Description		tripartite motif containing 69	splicing factor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	mRNA Splicing - Major Pathway
Drugs			Artenimol
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Urate levels ( 21768215)
Interacting Genes		28 interacting genes: APP ASNS ATP5MC1 DVL1 FAM110A FKBP1B HAUS1 HGS IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N ZNF483	43 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461
Entrez ID		140691	7536
HPRD ID		11518	03306
Ensembl ID		ENSG00000185880	ENSG00000168066
Uniprot IDs		H0YL66 Q86WT6	A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637
PDB IDs		4NQJ	1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX
Enriched GO Terms of Interacting Partners?
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