PFN2 and DLST

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	DLST
Description		profilin 2	dihydrolipoamide S-succinyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Nucleus Mitochondrion Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs		1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	15 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1
Entrez ID		5217	1743
HPRD ID		01451	00520
Ensembl ID		ENSG00000070087	ENSG00000119689
Uniprot IDs		P35080	A0A024R6C9 B7Z6J1 P36957
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?
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