PFN2 and DDX11

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	DDX11
Description		profilin 2	DEAD/H-box helicase 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Nuclear Chromatin Spindle Pole Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Midbody Mitotic Cohesin Complex Ctf18 RFC-like Complex Extracellular Exosome
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity RNA-dependent ATPase Activity Triplex DNA Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	DNA Repair Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Multicellular Organism Development Viral Process Replication Fork Processing Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding DNA Duplex Unwinding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding IRE1-mediated Unfolded Protein Response G-quadruplex DNA Unwinding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	XBP1(S) activates chaperone genes
Drugs		1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases			Warsaw breakage syndrome
GWAS
Interacting Genes		32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	3 interacting genes: KAT7 PFN2 PKP2
Entrez ID		5217	1663
HPRD ID		01451	03095
Ensembl ID		ENSG00000070087	ENSG00000013573
Uniprot IDs		P35080	Q2NKM7 Q96FC9
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?
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