DLST and UMPS

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		DLST	UMPS
Description		dihydrolipoamide S-succinyltransferase	uridine monophosphate synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Pyrimidine Nucleobase Biosynthetic Process Cellular Response To Drug 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process
Pathways		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)	Pyrimidine biosynthesis
Drugs			6-Hydroxyuridine-5'-Phosphate
Diseases			Orotic aciduria
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
Interacting Genes		15 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1	14 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 ZNF227
Entrez ID		1743	7372
HPRD ID		00520	02022
Ensembl ID		ENSG00000119689	ENSG00000114491
Uniprot IDs		A0A024R6C9 B7Z6J1 P36957	A8K5J1 P11172
PDB IDs			2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?
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