PFN2 and EVL

Number of citations of the paper that reports this interaction (PubMedID 10945997)
73

Data Source:
HPRD (in vitro)

		PFN2	EVL
Description		profilin 2	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Negative Regulation Of Ruffle Assembly
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs		1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
Diseases
GWAS			Blood protein levels ( 30072576) White matter hyperintensity burden ( 25663218)
Interacting Genes		32 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	30 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17
Entrez ID		5217	51466
HPRD ID		01451	10942
Ensembl ID		ENSG00000070087	ENSG00000196405
Uniprot IDs		P35080	A0A024R6K5 Q9UI08
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?
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