DLST and PAK4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	PAK4
Description		dihydrolipoamide S-succinyltransferase	p21 (RAC1) activated kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex	Cytoplasm Golgi Apparatus Adherens Junction Focal Adhesion
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Angiogenesis Dendritic Spine Development Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)	Activation of RAC1
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		15 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1	24 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ
Entrez ID		1743	10298
HPRD ID		00520	05675
Ensembl ID		ENSG00000119689	ENSG00000130669
Uniprot IDs		A0A024R6C9 B7Z6J1 P36957	A0A024R0J1 A0A024R0L8 O96013
PDB IDs			2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW
Enriched GO Terms of Interacting Partners?
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