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Novel |
IWS1 |
interacts with SUPT6H, CTD assembly factor 1 |
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Pre-transcription Events
- RNA Polymerase II Transcription Elongation
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Novel |
MARCO |
macrophage receptor with collagenous structure |
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
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- Titanium dioxide
- Silicon dioxide
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Novel |
MECOM |
MDS1 and EVI1 complex locus |
- PKMTs methylate histone lysines
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Formation of the nephric duct
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- Chronic myeloid leukemia (CML)
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Novel |
NIFK |
nucleolar protein interacting with the FHA domain of MKI67 |
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Novel |
SFT2D3 |
SFT2 domain containing 3 |
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Novel |
SGK2 |
serum/glucocorticoid regulated kinase 2 |
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ARID4B |
AT-rich interaction domain 4B |
- HDACs deacetylate histones
- NoRC negatively regulates rRNA expression
- Potential therapeutics for SARS
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CCR9 |
C-C motif chemokine receptor 9 |
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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CUL2 |
cullin 2 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Antigen processing: Ubiquitination & Proteasome degradation
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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GPS1 |
G protein pathway suppressor 1 |
- DNA Damage Recognition in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Cargo recognition for clathrin-mediated endocytosis
- Neddylation
- RHOBTB1 GTPase cycle
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MYC |
MYC proto-oncogene, bHLH transcription factor |
- Transcription of E2F targets under negative control by DREAM complex
- Signaling by ALK
- NOTCH1 Intracellular Domain Regulates Transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- MAPK6/MAPK4 signaling
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- RUNX3 regulates WNT signaling
- Estrogen-dependent gene expression
- Transcriptional regulation of granulopoiesis
- Regulation of CDH1 mRNA translation by microRNAs
- Regulation of NFE2L2 gene expression
- Regulation of PD-L1(CD274) transcription
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- Acetylsalicylic acid
- Dimethyl sulfoxide
- Doconexent
- Nadroparin
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- Penile cancer
- Breast cancer
- Laryngeal cancer
- Oral cancer
- Multiple myeloma
- Kaposi's sarcoma
- Ovarian cancer
- Choriocarcinoma
- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
- Burkitt lymphoma
- Small cell lung cancer
- Osteosarcoma
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
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SMAD3 |
SMAD family member 3 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Ub-specific processing proteases
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- Interleukin-37 signaling
- NOTCH4 Intracellular Domain Regulates Transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
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USP7 |
ubiquitin specific peptidase 7 |
- Ub-specific processing proteases
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Regulation of TP53 Degradation
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Regulation of PTEN localization
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