SAP130 and MARCO

		SAP130	MARCO
Description		Sin3A associated protein 130	macrophage receptor with collagenous structure
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Speck Sin3-type Complex	Collagen Trimer Cytoplasm Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function		Amyloid-beta Binding G Protein-coupled Receptor Binding Transmembrane Signaling Receptor Activity Cargo Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	Immune System Process Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Apoptotic Cell Clearance Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance
Pathways		HATs acetylate histones NoRC negatively regulates rRNA expression	Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs			Titanium dioxide Silicon dioxide
Diseases
GWAS		Anti-saccade response ( 29064472) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: ARID4B CCR9 CUL2 GPS1 MYC SMAD3 USP7	3 interacting genes: SCGB3A1 SCGB3A2 SNCA
Entrez ID		79595	8685
HPRD ID		18015	05337
Ensembl ID		ENSG00000136715	ENSG00000019169
Uniprot IDs		A0A2R8YDB8 H7BXF5 Q96DP1 Q9H0E3	Q4ZG40 Q9UEW3
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Remodeling Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization MAPK Cascade Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of MiRNA Transcription JNK Cascade Positive Regulation Of MiRNA Metabolic Process Regulation Of Intracellular Transport Epigenetic Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of MiRNA Transcription T Cell Activation Regulation Of Stem Cell Population Maintenance Myc-Max Complex Regulation Of Acinar Cell Proliferation Regulation Of Cellular Response To Growth Factor Stimulus Sterol Response Element Binding Regulation Of MiRNA Metabolic Process Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Apoptotic Signaling Pathway NK T Cell Proliferation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Symbiont-mediated Disruption Of Host Cell PML Body CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Microtubule Polymerization SNARE Complex Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Platelet Alpha Granule Membrane Dynein Complex Binding Synaptic Vesicle Priming Extracellular Space Dopamine Transport Inclusion Body Positive Regulation Of Receptor Recycling Neurotransmitter Reuptake Catecholamine Biosynthetic Process Cellular Response To Epinephrine Stimulus Response To Magnesium Ion Behavioral Response To Cocaine Phospholipase Binding Regulation Of Neurotransmitter Uptake
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