SAP130 and SGK2

		SAP130	SGK2
Description		Sin3A associated protein 130	serum/glucocorticoid regulated kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Speck Sin3-type Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance	Regulation Of Cell Growth Protein Phosphorylation Response To Oxidative Stress Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation
Pathways		HATs acetylate histones NoRC negatively regulates rRNA expression	Stimuli-sensing channels
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Daytime sleep phenotypes ( 27126917) Weight ( 34074324)
Interacting Genes		7 interacting genes: ARID4B CCR9 CUL2 GPS1 MYC SMAD3 USP7	9 interacting genes: APP DAPK1 HIRIP3 IL3RA NEDD4 NEDD4L PDPK1 PMM2 PTOV1
Entrez ID		79595	10110
HPRD ID		18015	06348
Ensembl ID		ENSG00000136715	ENSG00000101049
Uniprot IDs		A0A2R8YDB8 H7BXF5 Q96DP1 Q9H0E3	Q9HBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Remodeling Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization MAPK Cascade Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of MiRNA Transcription JNK Cascade Positive Regulation Of MiRNA Metabolic Process Regulation Of Intracellular Transport Epigenetic Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of MiRNA Transcription T Cell Activation Regulation Of Stem Cell Population Maintenance Myc-Max Complex Regulation Of Acinar Cell Proliferation Regulation Of Cellular Response To Growth Factor Stimulus Sterol Response Element Binding Regulation Of MiRNA Metabolic Process Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Apoptotic Signaling Pathway NK T Cell Proliferation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Symbiont-mediated Disruption Of Host Cell PML Body CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation	Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Neuromuscular Junction Development Regulation Of Toll-like Receptor Signaling Pathway Receptor Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Organization DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Dendrite Morphogenesis Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process 3-phosphoinositide-dependent Protein Kinase Activity H2A-H2B Histone Complex Chaperone Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Transport Interleukin-3 Receptor Activity Channel Inhibitor Activity Regulation Of Potassium Ion Transport Phosphomannomutase Activity GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
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