| Novel |
C3
|
complement C3 |
- Alternative complement activation
- Activation of C3 and C5
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Peptide ligand-binding receptors
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (i) signalling events
- Neutrophil degranulation
- Post-translational protein phosphorylation
- Purinergic signaling in leishmaniasis infection
- Regulation of Complement cascade
|
- Human immunoglobulin G
- Zinc
- S-Hydroxycysteine
- Mirococept
- Copper
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
- Pegcetacoplan
|
- Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
- Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
|
| Novel |
CALR
|
calreticulin |
- ER-Phagosome pathway
- Assembly of Viral Components at the Budding Site
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- Scavenging by Class F Receptors
- Scavenging by Class F Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Calnexin/calreticulin cycle
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
- Antihemophilic factor, human recombinant
- Tenecteplase
- Melatonin
- Lanoteplase
- Copper
- Calcium citrate
- Calcium Phosphate
- Lonoctocog alfa
- Moroctocog alfa
- Calcium phosphate dihydrate
|
|
| Novel |
EPOR
|
erythropoietin receptor |
- Signaling by Erythropoietin
- Signaling by Erythropoietin
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phospholipase C gamma (PLCG)
- Erythropoietin activates STAT5
- Erythropoietin activates RAS
- Erythropoietin activates RAS
|
- Darbepoetin alfa
- Erythropoietin
- Dibromotyrosine
- Peginesatide
- Methoxy polyethylene glycol-epoetin beta
|
- Congenital polycythemia; Familial erythrocytosis (ECYT)
|
| Novel |
GCC2
|
GRIP and coiled-coil domain containing 2 |
- Retrograde transport at the Trans-Golgi-Network
- Signaling by ALK fusions and activated point mutants
|
|
|
| Novel |
PRLR
|
prolactin receptor |
- Prolactin receptor signaling
- Prolactin receptor signaling
- Growth hormone receptor signaling
|
- Somatotropin
- Lonapegsomatropin
|
|
| Novel |
RFX2
|
regulatory factor X2 |
|
|
|
| Novel |
RPL18
|
ribosomal protein L18 |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Formation of a pool of free 40S subunits
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
|
|
|
| Novel |
TNFRSF1B
|
TNF receptor superfamily member 1B |
- TNFR2 non-canonical NF-kB pathway
- TNFs bind their physiological receptors
- Interleukin-10 signaling
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
|
|
- Graft-versus-host disease
|
| Novel |
USF2
|
upstream transcription factor 2, c-fos interacting |
- Estrogen-dependent gene expression
|
|
|
|
APP
|
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1-dependent IKK and NF-kappa-B activation
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
|
- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Gantenerumab
- Aducanumab
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
- Lecanemab
|
|
|
BRICD5
|
BRICHOS domain containing 5 |
|
|
|
|
CD209
|
CD209 molecule |
- CD209 (DC-SIGN) signaling
- Butyrophilin (BTN) family interactions
- RSV-host interactions
|
|
|
|
CLDN19
|
claudin 19 |
- Tight junction interactions
|
|
|
|
CLDN4
|
claudin 4 |
- Tight junction interactions
|
|
|
|
CLEC4M
|
C-type lectin domain family 4 member M |
|
|
|
|
EDDM3B
|
epididymal protein 3B |
|
|
|
|
EZR
|
ezrin |
- Netrin-1 signaling
- Recycling pathway of L1
- Recycling pathway of L1
- Sensory processing of sound by inner hair cells of the cochlea
- Sensory processing of sound by outer hair cells of the cochlea
|
|
|
|
ITGAD
|
integrin subunit alpha D |
- Integrin cell surface interactions
|
|
|
|
ITGAL
|
integrin subunit alpha L |
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Cell surface interactions at the vascular wall
- Integrin cell surface interactions
- Neutrophil degranulation
- RUNX3 Regulates Immune Response and Cell Migration
|
- Efalizumab
- Antithymocyte immunoglobulin (rabbit)
- Lovastatin
- Simvastatin
- Rosuvastatin
- 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
- LFA703
- (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide
- 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
- 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
- Pitavastatin
- Lifitegrast
|
|
|
ITGB2
|
integrin subunit beta 2 |
- Toll Like Receptor 4 (TLR4) Cascade
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Cell surface interactions at the vascular wall
- Integrin cell surface interactions
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
|
|
- Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
|