EIF4E2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CAB39	calcium binding protein 39	Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation
Novel	CCL24	C-C motif chemokine ligand 24
Novel	MVK	mevalonate kinase	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Farnesyl thiopyrophosphate	Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
Novel	PDE4DIP	phosphodiesterase 4D interacting protein
Novel	SAG	S-antigen visual arrestin	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
Novel	SP140	SP140 nuclear body protein
Novel	TGFBRAP1	transforming growth factor beta receptor associated protein 1
	ADAMTSL4	ADAMTS like 4	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins		Ectopia lentis
	AMOTL2	angiomotin like 2	Signaling by Hippo
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	Alzheimer's disease (AD)
	ARIH1	ariadne RBR E3 ubiquitin protein ligase 1	ISG15 antiviral mechanism RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
	ARIH2	ariadne RBR E3 ubiquitin protein ligase 2	Antigen processing: Ubiquitination & Proteasome degradation
	CARD9	caspase recruitment domain family member 9	NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
	CBY2	chibby family member 2
	CDR2	cerebellar degeneration related protein 2
	EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
	EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3
	EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1
	FBXO25	F-box protein 25
	HOMEZ	homeobox and leucine zipper encoding

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