Cancer - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols PRKCZ and WWC1	Name 1 protein kinase C zeta	Name2 WW and C2 domain containing 1	Pathway 1 GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Pathway 2 Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription	Drugs 1 Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PRKCZ and GLRX3	Name 1 protein kinase C zeta	Name2 glutaredoxin 3	Pathway 1 GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Pathway 2 Iron uptake and transport	Drugs 1 Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RHOG and ARHGDIG	Name 1 ras homolog family member G	Name2 Rho GDP dissociation inhibitor gamma	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 RHOB GTPase cycle CDC42 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RHOG and DOCK1	Name 1 ras homolog family member G	Name2 dedicator of cytokinesis 1	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RHOG and ELMO1	Name 1 ras homolog family member G	Name2 engulfment and cell motility 1	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAB5B and SUN2	Name 1 RAB5B, member RAS oncogene family	Name2 Sad1 and UNC84 domain containing 2	Pathway 1 Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry	Pathway 2 Meiotic synapsis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RALA and EXOC2	Name 1 RAS like proto-oncogene A	Name2 exocyst complex component 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Pathway 2 Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BRCA2 and FANCE	Name 1 BRCA2 DNA repair associated	Name2 FA complementation group E	Pathway 1 HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)	Pathway 2 Fanconi Anemia Pathway PKR-mediated signaling	Drugs 1	Drugs 2	Diseases 1 Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer	Diseases 2 Fanconi anemia
Novel Novel	Symbols RAD51 and TFF1	Name 1 RAD51 recombinase	Name2 trefoil factor 1	Pathway 1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Pathway 2 Estrogen-dependent gene expression	Drugs 1 Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib	Drugs 2 Raloxifene Afimoxifene	Diseases 1	Diseases 2
Novel Novel	Symbols RAD51 and FBXO5	Name 1 RAD51 recombinase	Name2 F-box protein 5	Pathway 1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Pathway 2 SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription	Drugs 1 Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RB1 and BNC2	Name 1 RB transcriptional corepressor 1	Name2 basonuclin zinc finger protein 2	Pathway 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome Nuclear events stimulated by ALK signaling in cancer Positive Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Breast cancer Osteosarcoma Hepatocellular carcinoma Small cell lung cancer Esophageal cancer Glioma Bladder cancer	Diseases 2
Novel Novel	Symbols RXRA and ROBO4	Name 1 retinoid X receptor alpha	Name2 roundabout guidance receptor 4	Pathway 1 BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Pathway 2	Drugs 1 alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RXRA and JAZF1	Name 1 retinoid X receptor alpha	Name2 JAZF zinc finger 1	Pathway 1 BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Pathway 2	Drugs 1 alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols LMO2 and N4BP2L2	Name 1 LIM domain only 2	Name2 NEDD4 binding protein 2 like 2	Pathway 1 RUNX1 regulates transcription of genes involved in differentiation of HSCs	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Diseases 2
Novel Novel	Symbols CYTH1 and ARFRP1	Name 1 cytohesin 1	Name2 ARF related protein 1	Pathway 1 Intra-Golgi traffic	Pathway 2 Retrograde transport at the Trans-Golgi-Network Retrograde transport at the Trans-Golgi-Network	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNRPB and GEMIN4	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 gem nuclear organelle associated protein 4	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2 snRNP Assembly SARS-CoV-2 modulates host translation machinery	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNRPB and RFX6	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 regulatory factor X6	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2 Regulation of gene expression in beta cells	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNRPB and C10orf55	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 chromosome 10 putative open reading frame 55	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNRPA and SNRPA1	Name 1 small nuclear ribonucleoprotein polypeptide A	Name2 small nuclear ribonucleoprotein polypeptide A'	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Drugs 1 Malonic acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNRPA and PAPOLA	Name 1 small nuclear ribonucleoprotein polypeptide A	Name2 poly(A) polymerase alpha	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Drugs 1 Malonic acid	Drugs 2 Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid	Diseases 1	Diseases 2
Novel	Symbols PRKCZ and WWC1	Name 1 protein kinase C zeta	Name2 WW and C2 domain containing 1	Pathway 1 GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Pathway 2 Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription	Drugs 1 Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PRKCZ and GLRX3	Name 1 protein kinase C zeta	Name2 glutaredoxin 3	Pathway 1 GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Pathway 2 Iron uptake and transport	Drugs 1 Tamoxifen Staurosporine Dequalinium Benzoyl peroxide	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RHOG and ARHGDIG	Name 1 ras homolog family member G	Name2 Rho GDP dissociation inhibitor gamma	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 RHOB GTPase cycle CDC42 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RHOG and DOCK1	Name 1 ras homolog family member G	Name2 dedicator of cytokinesis 1	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RHOG and ELMO1	Name 1 ras homolog family member G	Name2 engulfment and cell motility 1	Pathway 1 GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Pathway 2 Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAB5B and SUN2	Name 1 RAB5B, member RAS oncogene family	Name2 Sad1 and UNC84 domain containing 2	Pathway 1 Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry	Pathway 2 Meiotic synapsis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RALA and EXOC2	Name 1 RAS like proto-oncogene A	Name2 exocyst complex component 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Pathway 2 Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Drugs 1 Guanosine-5'-Diphosphate	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BRCA2 and FANCE	Name 1 BRCA2 DNA repair associated	Name2 FA complementation group E	Pathway 1 HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)	Pathway 2 Fanconi Anemia Pathway PKR-mediated signaling	Drugs 1	Drugs 2	Diseases 1 Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer	Diseases 2 Fanconi anemia
Novel	Symbols RAD51 and TFF1	Name 1 RAD51 recombinase	Name2 trefoil factor 1	Pathway 1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Pathway 2 Estrogen-dependent gene expression	Drugs 1 Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib	Drugs 2 Raloxifene Afimoxifene	Diseases 1	Diseases 2
Novel	Symbols RAD51 and FBXO5	Name 1 RAD51 recombinase	Name2 F-box protein 5	Pathway 1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Pathway 2 SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription	Drugs 1 Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RB1 and BNC2	Name 1 RB transcriptional corepressor 1	Name2 basonuclin zinc finger protein 2	Pathway 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome Nuclear events stimulated by ALK signaling in cancer Positive Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Breast cancer Osteosarcoma Hepatocellular carcinoma Small cell lung cancer Esophageal cancer Glioma Bladder cancer	Diseases 2
Novel	Symbols RXRA and ROBO4	Name 1 retinoid X receptor alpha	Name2 roundabout guidance receptor 4	Pathway 1 BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Pathway 2	Drugs 1 alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RXRA and JAZF1	Name 1 retinoid X receptor alpha	Name2 JAZF zinc finger 1	Pathway 1 BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Pathway 2	Drugs 1 alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols LMO2 and N4BP2L2	Name 1 LIM domain only 2	Name2 NEDD4 binding protein 2 like 2	Pathway 1 RUNX1 regulates transcription of genes involved in differentiation of HSCs	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Diseases 2
Novel	Symbols CYTH1 and ARFRP1	Name 1 cytohesin 1	Name2 ARF related protein 1	Pathway 1 Intra-Golgi traffic	Pathway 2 Retrograde transport at the Trans-Golgi-Network Retrograde transport at the Trans-Golgi-Network	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNRPB and GEMIN4	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 gem nuclear organelle associated protein 4	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2 snRNP Assembly SARS-CoV-2 modulates host translation machinery	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNRPB and RFX6	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 regulatory factor X6	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2 Regulation of gene expression in beta cells	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNRPB and C10orf55	Name 1 small nuclear ribonucleoprotein polypeptides B and B1	Name2 chromosome 10 putative open reading frame 55	Pathway 1 SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNRPA and SNRPA1	Name 1 small nuclear ribonucleoprotein polypeptide A	Name2 small nuclear ribonucleoprotein polypeptide A'	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Drugs 1 Malonic acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNRPA and PAPOLA	Name 1 small nuclear ribonucleoprotein polypeptide A	Name2 poly(A) polymerase alpha	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2 mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Drugs 1 Malonic acid	Drugs 2 Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid	Diseases 1	Diseases 2

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