Cancer - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols WT1 and B3GNT3	Name 1 WT1 transcription factor	Name2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	Pathway 1 Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development	Pathway 2 Keratan sulfate biosynthesis O-linked glycosylation of mucins PD-L1(CD274) glycosylation and translocation to plasma membrane	Drugs 1	Drugs 2	Diseases 1 Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Diseases 2
Novel Novel	Symbols DOC2A and HS3ST4	Name 1 double C2 domain alpha	Name2 heparan sulfate-glucosamine 3-sulfotransferase 4	Pathway 1	Pathway 2 HS-GAG biosynthesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NFRKB and OPCML	Name 1 nuclear factor related to kappaB binding protein	Name2 opioid binding protein/cell adhesion molecule like	Pathway 1 UCH proteinases DNA Damage Recognition in GG-NER	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AGPS and KCNH7	Name 1 alkylglycerone phosphate synthase	Name2 potassium voltage-gated channel subfamily H member 7	Pathway 1 Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Pathway 2 Voltage gated Potassium channels	Drugs 1	Drugs 2 Enflurane Ibutilide Amitriptyline Doxazosin Promethazine Miconazole Amiodarone Terazosin Vanoxerine Silodosin	Diseases 1 Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Diseases 2
Novel Novel	Symbols TBX1 and MORC3	Name 1 T-box transcription factor 1	Name2 MORC family CW-type zinc finger 3	Pathway 1 Cardiogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Velocardiofacial syndrome Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Diseases 2
Novel Novel	Symbols TUBB4A and SBNO2	Name 1 tubulin beta 4A class IVa	Name2 strawberry notch homolog 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Pathway 2	Drugs 1 Epothilone D Patupilone CYT997 ZEN-012 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PRR5 and SCUBE1	Name 1 proline rich 5	Name2 signal peptide, CUB domain and EGF like domain containing 1	Pathway 1 PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Pathway 2 Degradation of the extracellular matrix	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ATP6V1A and LSAMP	Name 1 ATPase H+ transporting V1 subunit A	Name2 limbic system associated membrane protein	Pathway 1 ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1 Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols COL15A1 and GAS1	Name 1 collagen type XV alpha 1 chain	Name2 growth arrest specific 1	Pathway 1 Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Pathway 2 Ligand-receptor interactions Activation of SMO	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TMA16 and FSTL5	Name 1 translation machinery associated 16 homolog	Name2 follistatin like 5	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FKBP15 and DELEC1	Name 1 FKBP prolyl isomerase family member 15	Name2 deleted in esophageal cancer 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CCDC91 and TMTC1	Name 1 coiled-coil domain containing 91	Name2 transmembrane O-mannosyltransferase targeting cadherins 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HIBCH and MFSD6	Name 1 3-hydroxyisobutyryl-CoA hydrolase	Name2 major facilitator superfamily domain containing 6	Pathway 1 Branched-chain amino acid catabolism 3-hydroxyisobutyryl-CoA hydrolase deficiency	Pathway 2	Drugs 1 Quercetin	Drugs 2	Diseases 1 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Diseases 2
Novel Novel	Symbols NAT1 and CSMD1	Name 1 N-acetyltransferase 1	Name2 CUB and Sushi multiple domains 1	Pathway 1 Acetylation Paracetamol ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ATP6V0B and BPI	Name 1 ATPase H+ transporting V0 subunit b	Name2 bactericidal permeability increasing protein	Pathway 1 ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Pathway 2 Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	Drugs 1 Tiludronic acid	Drugs 2 Di-Stearoyl-3-Sn-Phosphatidylcholine	Diseases 1	Diseases 2
Novel Novel	Symbols ADARB2 and LARP4B	Name 1 adenosine deaminase RNA specific B2 (inactive)	Name2 La ribonucleoprotein 4B	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CRTC3 and HAPLN3	Name 1 CREB regulated transcription coactivator 3	Name2 hyaluronan and proteoglycan link protein 3	Pathway 1 Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Pathway 2	Drugs 1	Drugs 2 Hyaluronic acid	Diseases 1	Diseases 2
Novel Novel	Symbols RAB2B and SLC25A21	Name 1 RAB2B, member RAS oncogene family	Name2 solute carrier family 25 member 21	Pathway 1 RAB geranylgeranylation	Pathway 2 Lysine catabolism	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HNRNPLL and ZNF311	Name 1 heterogeneous nuclear ribonucleoprotein L like	Name2 zinc finger protein 311	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ZDHHC8 and MICAL3	Name 1 zDHHC palmitoyltransferase 8	Name2 microtubule associated monooxygenase, calponin and LIM domain containing 3	Pathway 1 HDL assembly Maturation of spike protein	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols WT1 and B3GNT3	Name 1 WT1 transcription factor	Name2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	Pathway 1 Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development	Pathway 2 Keratan sulfate biosynthesis O-linked glycosylation of mucins PD-L1(CD274) glycosylation and translocation to plasma membrane	Drugs 1	Drugs 2	Diseases 1 Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Diseases 2
Novel	Symbols DOC2A and HS3ST4	Name 1 double C2 domain alpha	Name2 heparan sulfate-glucosamine 3-sulfotransferase 4	Pathway 1	Pathway 2 HS-GAG biosynthesis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NFRKB and OPCML	Name 1 nuclear factor related to kappaB binding protein	Name2 opioid binding protein/cell adhesion molecule like	Pathway 1 UCH proteinases DNA Damage Recognition in GG-NER	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AGPS and KCNH7	Name 1 alkylglycerone phosphate synthase	Name2 potassium voltage-gated channel subfamily H member 7	Pathway 1 Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Pathway 2 Voltage gated Potassium channels	Drugs 1	Drugs 2 Enflurane Ibutilide Amitriptyline Doxazosin Promethazine Miconazole Amiodarone Terazosin Vanoxerine Silodosin	Diseases 1 Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Diseases 2
Novel	Symbols TBX1 and MORC3	Name 1 T-box transcription factor 1	Name2 MORC family CW-type zinc finger 3	Pathway 1 Cardiogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Velocardiofacial syndrome Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Diseases 2
Novel	Symbols TUBB4A and SBNO2	Name 1 tubulin beta 4A class IVa	Name2 strawberry notch homolog 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Pathway 2	Drugs 1 Epothilone D Patupilone CYT997 ZEN-012 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PRR5 and SCUBE1	Name 1 proline rich 5	Name2 signal peptide, CUB domain and EGF like domain containing 1	Pathway 1 PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Pathway 2 Degradation of the extracellular matrix	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ATP6V1A and LSAMP	Name 1 ATPase H+ transporting V1 subunit A	Name2 limbic system associated membrane protein	Pathway 1 ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Pathway 2 Post-translational modification: synthesis of GPI-anchored proteins	Drugs 1 Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols COL15A1 and GAS1	Name 1 collagen type XV alpha 1 chain	Name2 growth arrest specific 1	Pathway 1 Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Pathway 2 Ligand-receptor interactions Activation of SMO	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TMA16 and FSTL5	Name 1 translation machinery associated 16 homolog	Name2 follistatin like 5	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FKBP15 and DELEC1	Name 1 FKBP prolyl isomerase family member 15	Name2 deleted in esophageal cancer 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CCDC91 and TMTC1	Name 1 coiled-coil domain containing 91	Name2 transmembrane O-mannosyltransferase targeting cadherins 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HIBCH and MFSD6	Name 1 3-hydroxyisobutyryl-CoA hydrolase	Name2 major facilitator superfamily domain containing 6	Pathway 1 Branched-chain amino acid catabolism 3-hydroxyisobutyryl-CoA hydrolase deficiency	Pathway 2	Drugs 1 Quercetin	Drugs 2	Diseases 1 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Diseases 2
Novel	Symbols NAT1 and CSMD1	Name 1 N-acetyltransferase 1	Name2 CUB and Sushi multiple domains 1	Pathway 1 Acetylation Paracetamol ADME	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ATP6V0B and BPI	Name 1 ATPase H+ transporting V0 subunit b	Name2 bactericidal permeability increasing protein	Pathway 1 ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Pathway 2 Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	Drugs 1 Tiludronic acid	Drugs 2 Di-Stearoyl-3-Sn-Phosphatidylcholine	Diseases 1	Diseases 2
Novel	Symbols ADARB2 and LARP4B	Name 1 adenosine deaminase RNA specific B2 (inactive)	Name2 La ribonucleoprotein 4B	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CRTC3 and HAPLN3	Name 1 CREB regulated transcription coactivator 3	Name2 hyaluronan and proteoglycan link protein 3	Pathway 1 Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Pathway 2	Drugs 1	Drugs 2 Hyaluronic acid	Diseases 1	Diseases 2
Novel	Symbols RAB2B and SLC25A21	Name 1 RAB2B, member RAS oncogene family	Name2 solute carrier family 25 member 21	Pathway 1 RAB geranylgeranylation	Pathway 2 Lysine catabolism	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HNRNPLL and ZNF311	Name 1 heterogeneous nuclear ribonucleoprotein L like	Name2 zinc finger protein 311	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ZDHHC8 and MICAL3	Name 1 zDHHC palmitoyltransferase 8	Name2 microtubule associated monooxygenase, calponin and LIM domain containing 3	Pathway 1 HDL assembly Maturation of spike protein	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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