CRTC3 and HAPLN3

		CRTC3	HAPLN3
Description		CREB regulated transcription coactivator 3	hyaluronan and proteoglycan link protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Synapse Perineuronal Net
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding	Hyaluronic Acid Binding
	Biological Process	Lipid Catabolic Process Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Cellular Response To CAMP Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Energy Homeostasis	Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways		Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Hyaluronic acid
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chromium levels ( 26025379) Chronic postoperative pain ( 31903573) Colorectal cancer ( 29228715) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 27485664) Heel bone mineral density ( 28869591) Inflammatory bowel disease ( 23128233 28067908) Information processing speed ( 21130836) Male-pattern baldness ( 28196072) Offspring birth weight ( 31043758) Response to exercise (triglyceride level interaction) ( 26491034) Ulcerative colitis ( 28067908)	Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Multiple keratinocyte cancers ( 28081215) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: CA13 KLHL12 SIK2 YAP1 YWHAG
Entrez ID		64784	145864
HPRD ID		13384	13629
Ensembl ID		ENSG00000140577	ENSG00000140511
Uniprot IDs		Q6UUV7	A8K7T8 H3BTH8 Q96S86
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Regulation Of Lipid Catabolic Process Macrophage Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To CAMP Energy Homeostasis Response To CAMP Protein Tetramerization Negative Regulation Of Lipid Metabolic Process Myeloid Leukocyte Activation Response To Purine-containing Compound Regulation Of G Protein-coupled Receptor Signaling Pathway
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